| Summary: | <i>Background.</i> Since physical activity has a high impact on patients with type 1 diabetes and the risk of hypoglycemia (low blood glucose levels) is significantly higher during and after physical activities, an automatic method to provide a personalized recommendation is needed to improve the blood glucose management and harness the benefits of physical activities. This paper aims to reduce the risk of hypoglycemia and hyperglycemia (high blood glucose levels), and empowers type 1 diabetes patients to make decisions regarding food choices connected with physical activities. <i>Methods.</i> Traditional and Bayesian feedforward neural network models are developed to provide accurate predictions of the blood glucose outcome and the risks of hyperglycemia and hypoglycemia with uncertainty information. Using the proposed models, safe actions that minimize the risk of both hypoglycemia and hyperglycemia are provided as food recommendations to the patient. <i>Results.</i> The predicted blood glucose responses to the optimal and safe food recommendations are significantly better and safer than by taking random food. <i>Conclusions.</i> Simulations conducted on the state-of-the-art UVA/Padova simulator combined with Brenton’s physical activity model show that the proposed methodology is safe and effective in managing blood glucose during and after physical activities.
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