Reactive microglia and IL1β/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina

Reactive microglia and IL1β/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina

Abstract Background Microglia and inflammation have context-specific impacts upon neuronal survival in different models of central nervous system (CNS) disease. Herein, we investigate how inflammatory mediators, including microglia, interleukin 1 beta (IL1β), and signaling through interleukin 1 rece...

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Bibliographic Details
Main Authors: Levi Todd, Isabella Palazzo, Lilianna Suarez, Xiaoyu Liu, Leo Volkov, Thanh V. Hoang, Warren A. Campbell, Seth Blackshaw, Ning Quan, Andy J. Fischer
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
IL1β
IL-1R1
Retinal neuroprotection
Online Access:http://link.springer.com/article/10.1186/s12974-019-1505-5

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