| Summary: | Aim: In the present study we aimed to check the
impact of maximal androgen deprivation therapy (MADT) on cellular blood
components such as hemoglobin (Hb) and hematocrit (Htc) fasting blood glucose (FBG), serum lipid values
and bone mineral density (BMD) in locally advanced prostate cancer.Patients and Methods: Having been treated with maximal
androgen blockade therapy, thirty-nine patients' initial values and at the
twelfth month values of hemoglobin (Hb), hematocrit (Htc), FBG, total
cholesterol (tChol), triglyceride (TG), high density lipoprotein (HDL), low density
lipoprotein (LDL) and spine BMD were recorded. Statistical comparisons of
initial and at the twelfth month values were performed. Results: A
statistically significant decrease was recorded in Hb and BMD values after one
year MADT. On the other hand, TG, tChol, LDL, HDL and FBG values showed a
statistically significant increase. Although Hb levels were significantly
reduced, none of our patients developed symptoms of anemia. Fourteen of 37
patients whose FBG levels were under 110 mg/dl before treatment, increased over
110 mg/dl at the twelfth month of treatment. Seven patients developed diabetes
mellitus (DM) after treatment. Moreover, T score evaluation revealed newly
developed osteoporosis in 4 patients. All of the patients with developed osteoporosis
had osteopenic T score values before treatment. No bone fractures occurred in
any of our patients.
Conclusion:
Our study points out the increase of FBG related to the treatment of MADT.
Decrease in BMD is higher in previously osteopenic patients. The lack of bone
fracture and anemia symptoms might be considered as a result of evaluation of
the early data on MADT.
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