Organophosphate Pesticide Exposure and Breast Cancer Risk: A Rapid Review of Human, Animal, and Cell-Based Studies
Background: Organophosphate pesticides (OPs) are one of the most commonly used classes of insecticides in the U.S., and metabolites of OPs have been detected in the urine of >75% of the U.S. population. While studies have shown that OP exposure is associated with risk of neurological diseases and...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-07-01
|
Series: | International Journal of Environmental Research and Public Health |
Subjects: | |
Online Access: | https://www.mdpi.com/1660-4601/17/14/5030 |
id |
doaj-6ecc08c3c2494d82b2d242f7d4c2ee57 |
---|---|
record_format |
Article |
spelling |
doaj-6ecc08c3c2494d82b2d242f7d4c2ee572020-11-25T03:46:11ZengMDPI AGInternational Journal of Environmental Research and Public Health1661-78271660-46012020-07-01175030503010.3390/ijerph17145030Organophosphate Pesticide Exposure and Breast Cancer Risk: A Rapid Review of Human, Animal, and Cell-Based StudiesKailynn June Yang0Jennifer Lee1Hannah Lui Park2Department of Epidemiology, School of Medicine, University of California, Irvine, CA 92697, USADepartment of Epidemiology, School of Medicine, University of California, Irvine, CA 92697, USADepartment of Epidemiology, School of Medicine, University of California, Irvine, CA 92697, USABackground: Organophosphate pesticides (OPs) are one of the most commonly used classes of insecticides in the U.S., and metabolites of OPs have been detected in the urine of >75% of the U.S. population. While studies have shown that OP exposure is associated with risk of neurological diseases and some cancers, the relationship between OP exposure and breast cancer risk is not well understood. Methods: The aim of this rapid review was to systematically evaluate published literature on the relationship between OP exposure and breast cancer risk, including both epidemiologic and laboratory studies. Twenty-seven full-text articles were reviewed by searching on Pubmed, EMBASE, and Cochrane databases. Results: Some human studies showed that malathion, terbufos, and chlorpyrifos were positively associated with human breast cancer risk, and some laboratory studies demonstrated that malathion and chlorpyrifos have estrogenic potential and other cancer-promoting properties. However, the human studies were limited in number, mostly included agricultural settings in several geographical areas in the U.S., and did not address cumulative exposure. Conclusions: Given the mixed results found in both human and laboratory studies, more research is needed to further examine the relationship between OP exposure and breast cancer risk, especially in humans in non-agricultural settings.https://www.mdpi.com/1660-4601/17/14/5030breast cancerorganophosphatespesticidescarcinogenicityendocrine disruptionanticholinesterase inhibition |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kailynn June Yang Jennifer Lee Hannah Lui Park |
spellingShingle |
Kailynn June Yang Jennifer Lee Hannah Lui Park Organophosphate Pesticide Exposure and Breast Cancer Risk: A Rapid Review of Human, Animal, and Cell-Based Studies International Journal of Environmental Research and Public Health breast cancer organophosphates pesticides carcinogenicity endocrine disruption anticholinesterase inhibition |
author_facet |
Kailynn June Yang Jennifer Lee Hannah Lui Park |
author_sort |
Kailynn June Yang |
title |
Organophosphate Pesticide Exposure and Breast Cancer Risk: A Rapid Review of Human, Animal, and Cell-Based Studies |
title_short |
Organophosphate Pesticide Exposure and Breast Cancer Risk: A Rapid Review of Human, Animal, and Cell-Based Studies |
title_full |
Organophosphate Pesticide Exposure and Breast Cancer Risk: A Rapid Review of Human, Animal, and Cell-Based Studies |
title_fullStr |
Organophosphate Pesticide Exposure and Breast Cancer Risk: A Rapid Review of Human, Animal, and Cell-Based Studies |
title_full_unstemmed |
Organophosphate Pesticide Exposure and Breast Cancer Risk: A Rapid Review of Human, Animal, and Cell-Based Studies |
title_sort |
organophosphate pesticide exposure and breast cancer risk: a rapid review of human, animal, and cell-based studies |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1661-7827 1660-4601 |
publishDate |
2020-07-01 |
description |
Background: Organophosphate pesticides (OPs) are one of the most commonly used classes of insecticides in the U.S., and metabolites of OPs have been detected in the urine of >75% of the U.S. population. While studies have shown that OP exposure is associated with risk of neurological diseases and some cancers, the relationship between OP exposure and breast cancer risk is not well understood. Methods: The aim of this rapid review was to systematically evaluate published literature on the relationship between OP exposure and breast cancer risk, including both epidemiologic and laboratory studies. Twenty-seven full-text articles were reviewed by searching on Pubmed, EMBASE, and Cochrane databases. Results: Some human studies showed that malathion, terbufos, and chlorpyrifos were positively associated with human breast cancer risk, and some laboratory studies demonstrated that malathion and chlorpyrifos have estrogenic potential and other cancer-promoting properties. However, the human studies were limited in number, mostly included agricultural settings in several geographical areas in the U.S., and did not address cumulative exposure. Conclusions: Given the mixed results found in both human and laboratory studies, more research is needed to further examine the relationship between OP exposure and breast cancer risk, especially in humans in non-agricultural settings. |
topic |
breast cancer organophosphates pesticides carcinogenicity endocrine disruption anticholinesterase inhibition |
url |
https://www.mdpi.com/1660-4601/17/14/5030 |
work_keys_str_mv |
AT kailynnjuneyang organophosphatepesticideexposureandbreastcancerriskarapidreviewofhumananimalandcellbasedstudies AT jenniferlee organophosphatepesticideexposureandbreastcancerriskarapidreviewofhumananimalandcellbasedstudies AT hannahluipark organophosphatepesticideexposureandbreastcancerriskarapidreviewofhumananimalandcellbasedstudies |
_version_ |
1724507280367419392 |