Acromegaly: Cardiovascular risk factors, cardiovascular manifestations and early vascular alterations in relation to disease activity

• Main Authors: Mullusoge Mariappa Harsha, Satyendra Tewari, Sushil Kumar Gupta, Roopali Khanna, Sudeep Kumar, Naveen Garg, Aditya Kapoor, Pravin K. Goel
• Format: Article
• Language: English
• Published: Elsevier 2021-07-01
• Series: Indian Heart Journal
• Subjects: Acromegaly; CIMT; Flow mediated dilatation
• Online Access: http://www.sciencedirect.com/science/article/pii/S0019483221001188

Acromegaly is associated with increased cardiovascular morbidity and mortality. 49 acromegaly patients were evaluated for presence of cardiovascular risk factors and manifestations using 2D-Echocardiography, strain, strain-rate, carotid intima media thickness (CIMT) and flow mediated dilatation (FMD) and correlated with disease activity. 32 patients with growth hormone (GH) level >1 ng/ml were considered active. Patients with active disease have more LV dysfunction as assessed by strain(p-0.031) and strain rate(p-0.001); trend towards lower ejection fraction(p-0.11) with significant correlation to GH(cc −0.252,p-0.05). Patient with active disease have reduced FMD(p- 0.042); with no difference in prevalence of cardiovascular risk factors and CIMT inrelation to disease activity.