The Impact of Diabetes Mellitus in COVID-19: A Mechanistic Review of Molecular Interactions

The Impact of Diabetes Mellitus in COVID-19: A Mechanistic Review of Molecular Interactions

The ongoing pandemic of COVID-19 is now the major issue in global health. Evidence implies that patients with diabetes are at a higher risk of severe disease or death due to COVID-19 than individuals without diabetes. However, the underlying mechanism for this differential effect in individuals with...

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Main Authors: Habib Yaribeygi, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Journal of Diabetes Research
Online Access:http://dx.doi.org/10.1155/2020/5436832
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spelling doaj-6ed582e955aa499a8dc9987f0414bcd02020-11-30T09:11:26ZengHindawi LimitedJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/54368325436832The Impact of Diabetes Mellitus in COVID-19: A Mechanistic Review of Molecular InteractionsHabib Yaribeygi0Thozhukat Sathyapalan1Tannaz Jamialahmadi2Amirhossein Sahebkar3Research Center of Physiology, Semnan University of Medical Sciences, Semnan, IranAcademic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, UKDepartment of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, IranBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 9177948564, IranThe ongoing pandemic of COVID-19 is now the major issue in global health. Evidence implies that patients with diabetes are at a higher risk of severe disease or death due to COVID-19 than individuals without diabetes. However, the underlying mechanism for this differential effect in individuals with and without diabetes is not clearly understood. We have reviewed the pathophysiological pathways which may facilitate the entry of virus or an increase in its infectivity in host cells in the diabetic milieu. We suggest that the preexisting pathological pathways in patients with poorly controlled diabetes increase the risk of infectivity and are responsible for the higher levels of tissue injury and death in patients with diabetes.http://dx.doi.org/10.1155/2020/5436832
collection DOAJ
language English
format Article
sources DOAJ
author Habib Yaribeygi
Thozhukat Sathyapalan
Tannaz Jamialahmadi
Amirhossein Sahebkar
spellingShingle Habib Yaribeygi
Thozhukat Sathyapalan
Tannaz Jamialahmadi
Amirhossein Sahebkar
The Impact of Diabetes Mellitus in COVID-19: A Mechanistic Review of Molecular Interactions
Journal of Diabetes Research
author_facet Habib Yaribeygi
Thozhukat Sathyapalan
Tannaz Jamialahmadi
Amirhossein Sahebkar
author_sort Habib Yaribeygi
title The Impact of Diabetes Mellitus in COVID-19: A Mechanistic Review of Molecular Interactions
title_short The Impact of Diabetes Mellitus in COVID-19: A Mechanistic Review of Molecular Interactions
title_full The Impact of Diabetes Mellitus in COVID-19: A Mechanistic Review of Molecular Interactions
title_fullStr The Impact of Diabetes Mellitus in COVID-19: A Mechanistic Review of Molecular Interactions
title_full_unstemmed The Impact of Diabetes Mellitus in COVID-19: A Mechanistic Review of Molecular Interactions
title_sort impact of diabetes mellitus in covid-19: a mechanistic review of molecular interactions
publisher Hindawi Limited
series Journal of Diabetes Research
issn 2314-6745
2314-6753
publishDate 2020-01-01
description The ongoing pandemic of COVID-19 is now the major issue in global health. Evidence implies that patients with diabetes are at a higher risk of severe disease or death due to COVID-19 than individuals without diabetes. However, the underlying mechanism for this differential effect in individuals with and without diabetes is not clearly understood. We have reviewed the pathophysiological pathways which may facilitate the entry of virus or an increase in its infectivity in host cells in the diabetic milieu. We suggest that the preexisting pathological pathways in patients with poorly controlled diabetes increase the risk of infectivity and are responsible for the higher levels of tissue injury and death in patients with diabetes.
url http://dx.doi.org/10.1155/2020/5436832
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