Efficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the EDTA ion gradient method.

Efficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the EDTA ion gradient method.

Liposomes act as efficient drug carriers. Recently, epirubicin (EPI) formulation was developed using a novel EDTA ion gradient method for drug encapsulation. This formulation displayed very good stability and drug retention in vitro in a two-year long-term stability experiment. The cryo-TEM images s...

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Main Authors: Jerzy Gubernator, Dominik Lipka, Mariola Korycińska, Katarzyna Kempińska, Magdalena Milczarek, Joanna Wietrzyk, Rafał Hrynyk, Sabine Barnert, Regine Süss, Arkadiusz Kozubek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24621591/?tool=EBI
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spelling doaj-6ed88cd774154c58842be34e310f3b092021-03-04T09:43:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e9148710.1371/journal.pone.0091487Efficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the EDTA ion gradient method.Jerzy GubernatorDominik LipkaMariola KorycińskaKatarzyna KempińskaMagdalena MilczarekJoanna WietrzykRafał HrynykSabine BarnertRegine SüssArkadiusz KozubekLiposomes act as efficient drug carriers. Recently, epirubicin (EPI) formulation was developed using a novel EDTA ion gradient method for drug encapsulation. This formulation displayed very good stability and drug retention in vitro in a two-year long-term stability experiment. The cryo-TEM images show drug precipitate structures different than ones formed with ammonium sulfate method, which is usually used to encapsulate anthracyclines. Its pharmacokinetic properties and its efficacy in the human breast MDA-MB-231 cancer xenograft model were also determined. The liposomal EPI formulation is eliminated slowly with an AUC of 7.6487, while the free drug has an AUC of only 0.0097. The formulation also had a much higher overall antitumor efficacy than the free drug.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24621591/?tool=EBI
collection DOAJ
language English
format Article
sources DOAJ
author Jerzy Gubernator
Dominik Lipka
Mariola Korycińska
Katarzyna Kempińska
Magdalena Milczarek
Joanna Wietrzyk
Rafał Hrynyk
Sabine Barnert
Regine Süss
Arkadiusz Kozubek
spellingShingle Jerzy Gubernator
Dominik Lipka
Mariola Korycińska
Katarzyna Kempińska
Magdalena Milczarek
Joanna Wietrzyk
Rafał Hrynyk
Sabine Barnert
Regine Süss
Arkadiusz Kozubek
Efficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the EDTA ion gradient method.
PLoS ONE
author_facet Jerzy Gubernator
Dominik Lipka
Mariola Korycińska
Katarzyna Kempińska
Magdalena Milczarek
Joanna Wietrzyk
Rafał Hrynyk
Sabine Barnert
Regine Süss
Arkadiusz Kozubek
author_sort Jerzy Gubernator
title Efficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the EDTA ion gradient method.
title_short Efficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the EDTA ion gradient method.
title_full Efficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the EDTA ion gradient method.
title_fullStr Efficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the EDTA ion gradient method.
title_full_unstemmed Efficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the EDTA ion gradient method.
title_sort efficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the edta ion gradient method.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2014-01-01
description Liposomes act as efficient drug carriers. Recently, epirubicin (EPI) formulation was developed using a novel EDTA ion gradient method for drug encapsulation. This formulation displayed very good stability and drug retention in vitro in a two-year long-term stability experiment. The cryo-TEM images show drug precipitate structures different than ones formed with ammonium sulfate method, which is usually used to encapsulate anthracyclines. Its pharmacokinetic properties and its efficacy in the human breast MDA-MB-231 cancer xenograft model were also determined. The liposomal EPI formulation is eliminated slowly with an AUC of 7.6487, while the free drug has an AUC of only 0.0097. The formulation also had a much higher overall antitumor efficacy than the free drug.
url https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24621591/?tool=EBI
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