Pilot study on novel blood containers with alternative plasticizers for red cell concentrate storage.
Di (2-ethylhexyl) phthalate (DEHP), a typical plasticizer used for polyvinyl chloride (PVC) blood containers, is eluted from the blood containers and exerts protective effects on red blood cells. However, a concern for detrimental effects of DEHP on human health has led to the development of potenti...
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doaj-6eda3c570b20418a900a368ea1911e352020-11-24T21:34:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01129e018573710.1371/journal.pone.0185737Pilot study on novel blood containers with alternative plasticizers for red cell concentrate storage.Yuki MorishitaYusuke NomuraChie FukuiTsuyoshi KawakamiToshiyuki IkedaTomokazu MukaiToshiyasu YubaKen-Ichi InamuraHisatoki YamaokaKen-Ichi MiyazakiHitoshi OkazakiYuji HaishimaDi (2-ethylhexyl) phthalate (DEHP), a typical plasticizer used for polyvinyl chloride (PVC) blood containers, is eluted from the blood containers and exerts protective effects on red blood cells. However, a concern for detrimental effects of DEHP on human health has led to the development of potential DEHP substitutes. Here, we compared the red blood cell preservation ability of two types of non-DEHP blood containers with safe alternative plasticizers to that of DEHP blood containers. Red cell concentrates in mannitol-adenine-phosphate solution (MAP/RCC) were stored for 6 weeks in PVC blood bags containing DEHP, di-isononyl-cyclohexane-1,2-dicarboxylate (DINCH) and di (2-ethylhexyl) 4-cyclohexene-1,2-dicarboxylate (DOTH), or 4-cyclohexene-1,2-dicarboxylic acid dinonyl ester (DL9TH) and DOTH. There was no significant difference in the total amount of plasticizer eluted into MAP/RCC (till 3 weeks from the beginning of the experiment), hemolysis of MAP/RCC, and osmotic fragility of MAP/RCC between the non-DEHP blood containers and DEHP blood containers. Hematological and blood chemical indices of MAP/RCC in all containers were nearly the same. Thus, DOTH/DINCH and DOTH/DL9TH blood containers demonstrate the same quality of MAP/RCC storing as the DEHP blood containers. Since DOTH, DINCH, and DL9TH were reported to be safe, DOTH/DINCH and DOTH/DL9TH blood containers are promising candidate substitutes for DEHP blood containers.http://europepmc.org/articles/PMC5619825?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuki Morishita Yusuke Nomura Chie Fukui Tsuyoshi Kawakami Toshiyuki Ikeda Tomokazu Mukai Toshiyasu Yuba Ken-Ichi Inamura Hisatoki Yamaoka Ken-Ichi Miyazaki Hitoshi Okazaki Yuji Haishima |
spellingShingle |
Yuki Morishita Yusuke Nomura Chie Fukui Tsuyoshi Kawakami Toshiyuki Ikeda Tomokazu Mukai Toshiyasu Yuba Ken-Ichi Inamura Hisatoki Yamaoka Ken-Ichi Miyazaki Hitoshi Okazaki Yuji Haishima Pilot study on novel blood containers with alternative plasticizers for red cell concentrate storage. PLoS ONE |
author_facet |
Yuki Morishita Yusuke Nomura Chie Fukui Tsuyoshi Kawakami Toshiyuki Ikeda Tomokazu Mukai Toshiyasu Yuba Ken-Ichi Inamura Hisatoki Yamaoka Ken-Ichi Miyazaki Hitoshi Okazaki Yuji Haishima |
author_sort |
Yuki Morishita |
title |
Pilot study on novel blood containers with alternative plasticizers for red cell concentrate storage. |
title_short |
Pilot study on novel blood containers with alternative plasticizers for red cell concentrate storage. |
title_full |
Pilot study on novel blood containers with alternative plasticizers for red cell concentrate storage. |
title_fullStr |
Pilot study on novel blood containers with alternative plasticizers for red cell concentrate storage. |
title_full_unstemmed |
Pilot study on novel blood containers with alternative plasticizers for red cell concentrate storage. |
title_sort |
pilot study on novel blood containers with alternative plasticizers for red cell concentrate storage. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
Di (2-ethylhexyl) phthalate (DEHP), a typical plasticizer used for polyvinyl chloride (PVC) blood containers, is eluted from the blood containers and exerts protective effects on red blood cells. However, a concern for detrimental effects of DEHP on human health has led to the development of potential DEHP substitutes. Here, we compared the red blood cell preservation ability of two types of non-DEHP blood containers with safe alternative plasticizers to that of DEHP blood containers. Red cell concentrates in mannitol-adenine-phosphate solution (MAP/RCC) were stored for 6 weeks in PVC blood bags containing DEHP, di-isononyl-cyclohexane-1,2-dicarboxylate (DINCH) and di (2-ethylhexyl) 4-cyclohexene-1,2-dicarboxylate (DOTH), or 4-cyclohexene-1,2-dicarboxylic acid dinonyl ester (DL9TH) and DOTH. There was no significant difference in the total amount of plasticizer eluted into MAP/RCC (till 3 weeks from the beginning of the experiment), hemolysis of MAP/RCC, and osmotic fragility of MAP/RCC between the non-DEHP blood containers and DEHP blood containers. Hematological and blood chemical indices of MAP/RCC in all containers were nearly the same. Thus, DOTH/DINCH and DOTH/DL9TH blood containers demonstrate the same quality of MAP/RCC storing as the DEHP blood containers. Since DOTH, DINCH, and DL9TH were reported to be safe, DOTH/DINCH and DOTH/DL9TH blood containers are promising candidate substitutes for DEHP blood containers. |
url |
http://europepmc.org/articles/PMC5619825?pdf=render |
work_keys_str_mv |
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