Potential Role of Vascular Endothelial Growth Factor, Interleukin-8 and Monocyte Chemoattractant Protein-1 in Periodontal Diseases
Host-mediated immunoinflammatory pathways activated by bacteria lead to destruction of the periodontal connective tissues and alveolar bone. The objective of this study was to elucidate the activation of the inflammatory processes in periodontal disease by quantitative assessment of cytokines and pe...
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doaj-6edf51f0900e41e3af9ee9f37055320e2020-11-24T21:28:52ZengWileyKaohsiung Journal of Medical Sciences1607-551X2003-08-0119840641410.1016/S1607-551X(09)70484-XPotential Role of Vascular Endothelial Growth Factor, Interleukin-8 and Monocyte Chemoattractant Protein-1 in Periodontal DiseasesEn LeeYa-Ping HoKun-Yen HoChi-Cheng TsaiHost-mediated immunoinflammatory pathways activated by bacteria lead to destruction of the periodontal connective tissues and alveolar bone. The objective of this study was to elucidate the activation of the inflammatory processes in periodontal disease by quantitative assessment of cytokines and periodontopathogens. Gingival crevicular fluids (GCF) and subgingival plaque samples were collected from patients with chronic periodontitis and gingivitis and from periodontally healthy sites. Vascular endothelial growth factor (VEGF), monocyte chemoattractant protein-1 (MCP-1), and interleukin 8 (IL-8) in GCF were analyzed by enzyme-linked immunosorbent assay. Periodontopathogens, including Bacteroides forsythus, Campylobacter rectus, Porphyromonas gingivalis and Prevotella intermedia, were analyzed by immunofluorescence and dark-field microscopy. There was significantly more VEGF and IL-8 in chronic periodontitis and gingivitis sites than in periodontally healthy sites. There were significant positive correlations between the concentrations and total amounts of VEGF and IL-8 in chronic periodontitis and gingivitis sites, and between the levels of periodontopathogens and the total amounts of VEGF, MCP-1 and IL-8. These data indicate that inflammatory processes induced by periodontopathogens and the activation of certain cytokines (VEGF, MCP-1, IL-8) in periodontal diseases may be relevant to host-mediated destruction in chronic periodontitis.http://www.sciencedirect.com/science/article/pii/S1607551X0970484Xvascular endothelial growth factorcytokineschemokinesperiodontopathogensperiodontal disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
En Lee Ya-Ping Ho Kun-Yen Ho Chi-Cheng Tsai |
spellingShingle |
En Lee Ya-Ping Ho Kun-Yen Ho Chi-Cheng Tsai Potential Role of Vascular Endothelial Growth Factor, Interleukin-8 and Monocyte Chemoattractant Protein-1 in Periodontal Diseases Kaohsiung Journal of Medical Sciences vascular endothelial growth factor cytokines chemokines periodontopathogens periodontal disease |
author_facet |
En Lee Ya-Ping Ho Kun-Yen Ho Chi-Cheng Tsai |
author_sort |
En Lee |
title |
Potential Role of Vascular Endothelial Growth Factor, Interleukin-8 and Monocyte Chemoattractant Protein-1 in Periodontal Diseases |
title_short |
Potential Role of Vascular Endothelial Growth Factor, Interleukin-8 and Monocyte Chemoattractant Protein-1 in Periodontal Diseases |
title_full |
Potential Role of Vascular Endothelial Growth Factor, Interleukin-8 and Monocyte Chemoattractant Protein-1 in Periodontal Diseases |
title_fullStr |
Potential Role of Vascular Endothelial Growth Factor, Interleukin-8 and Monocyte Chemoattractant Protein-1 in Periodontal Diseases |
title_full_unstemmed |
Potential Role of Vascular Endothelial Growth Factor, Interleukin-8 and Monocyte Chemoattractant Protein-1 in Periodontal Diseases |
title_sort |
potential role of vascular endothelial growth factor, interleukin-8 and monocyte chemoattractant protein-1 in periodontal diseases |
publisher |
Wiley |
series |
Kaohsiung Journal of Medical Sciences |
issn |
1607-551X |
publishDate |
2003-08-01 |
description |
Host-mediated immunoinflammatory pathways activated by bacteria lead to destruction of the periodontal connective tissues and alveolar bone. The objective of this study was to elucidate the activation of the inflammatory processes in periodontal disease by quantitative assessment of cytokines and periodontopathogens. Gingival crevicular fluids (GCF) and subgingival plaque samples were collected from patients with chronic periodontitis and gingivitis and from periodontally healthy sites. Vascular endothelial growth factor (VEGF), monocyte chemoattractant protein-1 (MCP-1), and interleukin 8 (IL-8) in GCF were analyzed by enzyme-linked immunosorbent assay. Periodontopathogens, including Bacteroides forsythus, Campylobacter rectus, Porphyromonas gingivalis and Prevotella intermedia, were analyzed by immunofluorescence and dark-field microscopy. There was significantly more VEGF and IL-8 in chronic periodontitis and gingivitis sites than in periodontally healthy sites. There were significant positive correlations between the concentrations and total amounts of VEGF and IL-8 in chronic periodontitis and gingivitis sites, and between the levels of periodontopathogens and the total amounts of VEGF, MCP-1 and IL-8. These data indicate that inflammatory processes induced by periodontopathogens and the activation of certain cytokines (VEGF, MCP-1, IL-8) in periodontal diseases may be relevant to host-mediated destruction in chronic periodontitis. |
topic |
vascular endothelial growth factor cytokines chemokines periodontopathogens periodontal disease |
url |
http://www.sciencedirect.com/science/article/pii/S1607551X0970484X |
work_keys_str_mv |
AT enlee potentialroleofvascularendothelialgrowthfactorinterleukin8andmonocytechemoattractantprotein1inperiodontaldiseases AT yapingho potentialroleofvascularendothelialgrowthfactorinterleukin8andmonocytechemoattractantprotein1inperiodontaldiseases AT kunyenho potentialroleofvascularendothelialgrowthfactorinterleukin8andmonocytechemoattractantprotein1inperiodontaldiseases AT chichengtsai potentialroleofvascularendothelialgrowthfactorinterleukin8andmonocytechemoattractantprotein1inperiodontaldiseases |
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1725968826248462336 |