Relationship between local and systemic inflammatory response and prognosis in laryngeal squamous cell carcinoma
OBJECTIVE: Laryngeal squamous cell carcinoma (LSCC) is the most frequently seen head and neck malignancy. Despite improvements in the treatment modalities within the last 20 years, the desired improvement in survival outcomes has not been achieved yet which led researchers to investigate factors tha...
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doaj-6eef23059543402787719aecea091f942021-01-24T18:40:59ZengKARE Publishingİstanbul Kuzey Klinikleri2148-49022020-03-017218018410.14744/nci.2019.02328NCI-02328Relationship between local and systemic inflammatory response and prognosis in laryngeal squamous cell carcinomaÜlkü Küçük0Sümeyye Ekmekçi1Pınar Bozkurt2Suphi Bulgurcu3İbrahim Çukurova4Department of Pathology, Tepecik Training and Research Hospital, Izmir, TurkeyDepartment of Pathology, Tepecik Training and Research Hospital, Izmir, TurkeyDepartment of Pathology, Tepecik Training and Research Hospital, Izmir, TurkeyDepartment of Otorhinolaryngology, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, TurkeyDepartment of Otorhinolaryngology, Tepecik Training and Research Hospital, Istanbul, TurkeyOBJECTIVE: Laryngeal squamous cell carcinoma (LSCC) is the most frequently seen head and neck malignancy. Despite improvements in the treatment modalities within the last 20 years, the desired improvement in survival outcomes has not been achieved yet which led researchers to investigate factors that might affect prognosis in LSCCs. METHODS: A total of 116 previously operated patients were included in this study. To assess systemic inflammation, neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) were calculated. The cut–off values for NLR and PLR were accepted as 2.79 and 112, respectively. To evaluate intratumoral inflammation, hematoxylin-eosin stained tumor sections were evaluated. Tumor-infiltrating lymphocyte (TIL) densities in the tumor area were scored as 1+, 2+ and 3+. RESULTS: The mean overall survival was 29.5+-17.7 months. In univariate analysis, a statistically significant correlation was seen between age group of 60 years, tumor stage, site and OS (p=0.025, p=0.026, p=0.029). There was no statistically significant relationship between PLR, NLR and TIL density and OS. In the multivariate analysis, the 60-year-old group and tumour stage were still significantly associated with the OS (p=0.033, p=0.046). CONCLUSION: Age and tumor stage were significantly associated with survival in our study, but contrary to the literature, no correlation was found between local and systemic inflammatory response.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-02328inflammationlaryngeal carcinoma; prognosis. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ülkü Küçük Sümeyye Ekmekçi Pınar Bozkurt Suphi Bulgurcu İbrahim Çukurova |
spellingShingle |
Ülkü Küçük Sümeyye Ekmekçi Pınar Bozkurt Suphi Bulgurcu İbrahim Çukurova Relationship between local and systemic inflammatory response and prognosis in laryngeal squamous cell carcinoma İstanbul Kuzey Klinikleri inflammation laryngeal carcinoma; prognosis. |
author_facet |
Ülkü Küçük Sümeyye Ekmekçi Pınar Bozkurt Suphi Bulgurcu İbrahim Çukurova |
author_sort |
Ülkü Küçük |
title |
Relationship between local and systemic inflammatory response and prognosis in laryngeal squamous cell carcinoma |
title_short |
Relationship between local and systemic inflammatory response and prognosis in laryngeal squamous cell carcinoma |
title_full |
Relationship between local and systemic inflammatory response and prognosis in laryngeal squamous cell carcinoma |
title_fullStr |
Relationship between local and systemic inflammatory response and prognosis in laryngeal squamous cell carcinoma |
title_full_unstemmed |
Relationship between local and systemic inflammatory response and prognosis in laryngeal squamous cell carcinoma |
title_sort |
relationship between local and systemic inflammatory response and prognosis in laryngeal squamous cell carcinoma |
publisher |
KARE Publishing |
series |
İstanbul Kuzey Klinikleri |
issn |
2148-4902 |
publishDate |
2020-03-01 |
description |
OBJECTIVE: Laryngeal squamous cell carcinoma (LSCC) is the most frequently seen head and neck malignancy. Despite improvements in the treatment modalities within the last 20 years, the desired improvement in survival outcomes has not been achieved yet which led researchers to investigate factors that might affect prognosis in LSCCs.
METHODS: A total of 116 previously operated patients were included in this study. To assess systemic inflammation, neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) were calculated. The cut–off values for NLR and PLR were accepted as 2.79 and 112, respectively. To evaluate intratumoral inflammation, hematoxylin-eosin stained tumor sections were evaluated. Tumor-infiltrating lymphocyte (TIL) densities in the tumor area were scored as 1+, 2+ and 3+.
RESULTS: The mean overall survival was 29.5+-17.7 months. In univariate analysis, a statistically significant correlation was seen between age group of 60 years, tumor stage, site and OS (p=0.025, p=0.026, p=0.029). There was no statistically significant relationship between PLR, NLR and TIL density and OS. In the multivariate analysis, the 60-year-old group and tumour stage were still significantly associated with the OS (p=0.033, p=0.046).
CONCLUSION: Age and tumor stage were significantly associated with survival in our study, but contrary to the literature, no correlation was found between local and systemic inflammatory response. |
topic |
inflammation laryngeal carcinoma; prognosis. |
url |
https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-02328 |
work_keys_str_mv |
AT ulkukucuk relationshipbetweenlocalandsystemicinflammatoryresponseandprognosisinlaryngealsquamouscellcarcinoma AT sumeyyeekmekci relationshipbetweenlocalandsystemicinflammatoryresponseandprognosisinlaryngealsquamouscellcarcinoma AT pınarbozkurt relationshipbetweenlocalandsystemicinflammatoryresponseandprognosisinlaryngealsquamouscellcarcinoma AT suphibulgurcu relationshipbetweenlocalandsystemicinflammatoryresponseandprognosisinlaryngealsquamouscellcarcinoma AT ibrahimcukurova relationshipbetweenlocalandsystemicinflammatoryresponseandprognosisinlaryngealsquamouscellcarcinoma |
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1724324832201408512 |