Trypanosoma cruzi: analysis of two different strains after piplartine treatment

Trypanosoma cruzi: analysis of two different strains after piplartine treatment

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The hemoflagellate protozoan, Trypanosoma cruzi, mainly transmitted by triatomine insects through blood transfusion or from mother-to-child, causes Chagas’ disease. This is a serious parasitic disease that occurs in Latin America, with considerable social and economic impact. Nifurtimox and benznida...

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Main Authors: Gabriela Alves Licursi Vieira, Marco Túlio Alves da Silva, Luis Octávio Regasini, Fernando Cotinguiba, Helen Julie Laure, José César Rosa, Maysa Furlan, Regina Maria Barretto Cicarelli
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Brazilian Journal of Infectious Diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S1413867017308899
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spelling doaj-6ef6efbe4f1e4dad92b9ec120bcf0e532020-11-25T03:56:13ZengElsevierBrazilian Journal of Infectious Diseases1413-86702018-05-01223208218Trypanosoma cruzi: analysis of two different strains after piplartine treatmentGabriela Alves Licursi Vieira0Marco Túlio Alves da Silva1Luis Octávio Regasini2Fernando Cotinguiba3Helen Julie Laure4José César Rosa5Maysa Furlan6Regina Maria Barretto Cicarelli7Universidade Estadual Paulista – UNESP, Instituto de Química, Araraquara, SP, BrazilUniversidade de São Paulo, Instituto de Física de São Carlos, São Carlos, SP, Brazil; Corresponding authors.Universidade Estadual Paulista – UNESP, Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Preto, SP, BrazilUniversidade Estadual Paulista – UNESP, Instituto de Química, Araraquara, SP, Brazil; Instituto de Pesquisas de Produtos Naturais (IPPN), Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, BrazilUniversidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Centro de Química de Proteínas, Ribeirão Preto, SP, BrazilUniversidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Centro de Química de Proteínas, Ribeirão Preto, SP, BrazilUniversidade Estadual Paulista – UNESP, Instituto de Química, Araraquara, SP, BrazilUniversidade Estadual Paulista – UNESP, Faculdade de Ciências Farmacêuticas, Araraquara, SP, Brazil; Corresponding authors.The hemoflagellate protozoan, Trypanosoma cruzi, mainly transmitted by triatomine insects through blood transfusion or from mother-to-child, causes Chagas’ disease. This is a serious parasitic disease that occurs in Latin America, with considerable social and economic impact. Nifurtimox and benznidazole, drugs indicated for treating infected persons, are effective in the acute phase, but poorly effective during the chronic phase. Therefore, it is extremely urgent to find innovative chemotherapeutic agents and/or effective vaccines. Since piplartine has several biological activities, including trypanocidal activity, the present study aimed to evaluate it on two T. cruzi strains proteome. Considerable changes in the expression of some important enzymes involved in parasite protection against oxidative stress, such as tryparedoxin peroxidase (TXNPx) and methionine sulfoxide reductase (MSR) was observed in both strains. These findings suggest that blocking the expression of the two enzymes could be potential targets for therapeutic studies. Keywords: Trypanosomatids, Proteome, Piplartine, Therapeutic targetshttp://www.sciencedirect.com/science/article/pii/S1413867017308899
collection DOAJ
language English
format Article
sources DOAJ
author Gabriela Alves Licursi Vieira
Marco Túlio Alves da Silva
Luis Octávio Regasini
Fernando Cotinguiba
Helen Julie Laure
José César Rosa
Maysa Furlan
Regina Maria Barretto Cicarelli
spellingShingle Gabriela Alves Licursi Vieira
Marco Túlio Alves da Silva
Luis Octávio Regasini
Fernando Cotinguiba
Helen Julie Laure
José César Rosa
Maysa Furlan
Regina Maria Barretto Cicarelli
Trypanosoma cruzi: analysis of two different strains after piplartine treatment
Brazilian Journal of Infectious Diseases
author_facet Gabriela Alves Licursi Vieira
Marco Túlio Alves da Silva
Luis Octávio Regasini
Fernando Cotinguiba
Helen Julie Laure
José César Rosa
Maysa Furlan
Regina Maria Barretto Cicarelli
author_sort Gabriela Alves Licursi Vieira
title Trypanosoma cruzi: analysis of two different strains after piplartine treatment
title_short Trypanosoma cruzi: analysis of two different strains after piplartine treatment
title_full Trypanosoma cruzi: analysis of two different strains after piplartine treatment
title_fullStr Trypanosoma cruzi: analysis of two different strains after piplartine treatment
title_full_unstemmed Trypanosoma cruzi: analysis of two different strains after piplartine treatment
title_sort trypanosoma cruzi: analysis of two different strains after piplartine treatment
publisher Elsevier
series Brazilian Journal of Infectious Diseases
issn 1413-8670
publishDate 2018-05-01
description The hemoflagellate protozoan, Trypanosoma cruzi, mainly transmitted by triatomine insects through blood transfusion or from mother-to-child, causes Chagas’ disease. This is a serious parasitic disease that occurs in Latin America, with considerable social and economic impact. Nifurtimox and benznidazole, drugs indicated for treating infected persons, are effective in the acute phase, but poorly effective during the chronic phase. Therefore, it is extremely urgent to find innovative chemotherapeutic agents and/or effective vaccines. Since piplartine has several biological activities, including trypanocidal activity, the present study aimed to evaluate it on two T. cruzi strains proteome. Considerable changes in the expression of some important enzymes involved in parasite protection against oxidative stress, such as tryparedoxin peroxidase (TXNPx) and methionine sulfoxide reductase (MSR) was observed in both strains. These findings suggest that blocking the expression of the two enzymes could be potential targets for therapeutic studies. Keywords: Trypanosomatids, Proteome, Piplartine, Therapeutic targets
url http://www.sciencedirect.com/science/article/pii/S1413867017308899
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