Redefining mouse transgenesis with CRISPR/Cas9 genome editing technology
Abstract The generation of genetically modified alleles in mice using conventional transgenesis technologies is a long and inefficient process. A new study shows that the in situ delivery of CRISPR/Cas9 reagents into pregnant mice results in a high efficiency of editing, and enables the rapid genera...
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2018-02-01
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| Series: | Genome Biology |
| Online Access: | http://link.springer.com/article/10.1186/s13059-018-1409-1 |
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doaj-6efd729aa30f4ba0a594e7c6e86c89e52020-11-24T20:51:28ZengBMCGenome Biology1474-760X2018-02-011911310.1186/s13059-018-1409-1Redefining mouse transgenesis with CRISPR/Cas9 genome editing technologyGaetan Burgio0Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National UniversityAbstract The generation of genetically modified alleles in mice using conventional transgenesis technologies is a long and inefficient process. A new study shows that the in situ delivery of CRISPR/Cas9 reagents into pregnant mice results in a high efficiency of editing, and enables the rapid generation of both simple and complex alleles.http://link.springer.com/article/10.1186/s13059-018-1409-1 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Gaetan Burgio |
| spellingShingle |
Gaetan Burgio Redefining mouse transgenesis with CRISPR/Cas9 genome editing technology Genome Biology |
| author_facet |
Gaetan Burgio |
| author_sort |
Gaetan Burgio |
| title |
Redefining mouse transgenesis with CRISPR/Cas9 genome editing technology |
| title_short |
Redefining mouse transgenesis with CRISPR/Cas9 genome editing technology |
| title_full |
Redefining mouse transgenesis with CRISPR/Cas9 genome editing technology |
| title_fullStr |
Redefining mouse transgenesis with CRISPR/Cas9 genome editing technology |
| title_full_unstemmed |
Redefining mouse transgenesis with CRISPR/Cas9 genome editing technology |
| title_sort |
redefining mouse transgenesis with crispr/cas9 genome editing technology |
| publisher |
BMC |
| series |
Genome Biology |
| issn |
1474-760X |
| publishDate |
2018-02-01 |
| description |
Abstract The generation of genetically modified alleles in mice using conventional transgenesis technologies is a long and inefficient process. A new study shows that the in situ delivery of CRISPR/Cas9 reagents into pregnant mice results in a high efficiency of editing, and enables the rapid generation of both simple and complex alleles. |
| url |
http://link.springer.com/article/10.1186/s13059-018-1409-1 |
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AT gaetanburgio redefiningmousetransgenesiswithcrisprcas9genomeeditingtechnology |
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