Soluble and Exosome-Bound α-Galactosylceramide Mediate Preferential Proliferation of Educated NK Cells with Increased Anti-Tumor Capacity

Soluble and Exosome-Bound α-Galactosylceramide Mediate Preferential Proliferation of Educated NK Cells with Increased Anti-Tumor Capacity

Natural killer (NK) cells can kill target cells via the recognition of stress molecules and down-regulation of major histocompatibility complex class I (MHC-I). Some NK cells are educated to recognize and kill cells that have lost their MHC-I expression, e.g., tumor or virus-infected cells. A desire...

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Bibliographic Details
Main Authors: Arnika K. Wagner, Ulf Gehrmann, Stefanie Hiltbrunner, Valentina Carannante, Thuy T. Luu, Tanja I. Näslund, Hanna Brauner, Nadir Kadri, Klas Kärre, Susanne Gabrielsson
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
extracellular vesicles
exosomes
natural killer (NK) cells
innate anti-tumor response
missing-self response
antitumor immunity
Online Access:https://www.mdpi.com/2072-6694/13/2/298

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