Zebrafish mbnl mutants model physical and molecular phenotypes of myotonic dystrophy

Zebrafish mbnl mutants model physical and molecular phenotypes of myotonic dystrophy

The muscleblind RNA-binding proteins (MBNL1, MBNL2 and MBNL3) are highly conserved across vertebrates and are important regulators of RNA alternative splicing. Loss of MBNL protein function through sequestration by CUG or CCUG RNA repeats is largely responsible for the phenotypes of the human geneti...

Full description

Bibliographic Details
Main Authors: Melissa N. Hinman, Jared I. Richardson, Rose A. Sockol, Eliza D. Aronson, Sarah J. Stednitz, Katrina N. Murray, J. Andrew Berglund, Karen Guillemin
Format: Article
Language:English
Published: The Company of Biologists 2021-06-01
Series:Disease Models & Mechanisms
Subjects:
mbnl1
mbnl2
mbnl3
myotonic dystrophy
zebrafish disease models
Online Access:http://dmm.biologists.org/content/14/6/dmm045773

Internet

http://dmm.biologists.org/content/14/6/dmm045773

Similar Items