Cortical Damage Associated With Cognitive and Motor Impairment in Hereditary Spastic Paraplegia: Evidence of a Novel SPAST Mutation

Cortical Damage Associated With Cognitive and Motor Impairment in Hereditary Spastic Paraplegia: Evidence of a Novel SPAST Mutation

To determine the cortical mechanism that underlies the cognitive impairment and motor disability in hereditary spastic paraplegia (HSP), nine HSP patients from a Chinese family were examined using clinical evaluation, cognitive screening, and genetic testing. Controls were matched healthy subjects....

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Bibliographic Details
Main Authors: Jian-zhong Lin, Hong-hua Zheng, Qi-lin Ma, Chen Wang, Li-ping Fan, Han-ming Wu, Dan-ni Wang, Jia-xing Zhang, Yi-hong Zhan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Neurology
Subjects:
SPAST gene mutation
SPG4-hereditary spastic paraplegia
MRI
brain
gray-matter changes
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2020.00399/full

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https://www.frontiersin.org/article/10.3389/fneur.2020.00399/full

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