IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release

The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine releas...

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Main Authors:	U. Westin, E. Lundberg, K. Ohlsson
Format:	Article
Language:	English
Published:	Hindawi Limited 1998-01-01
Series:	Mediators of Inflammation
Subjects:	SLPI IgE chymase histamine nasal mucosa.
Online Access:	http://dx.doi.org/10.1080/09629359891162

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spelling	doaj-6f13f03a40364647a25a138903ffc1892020-11-25T01:04:42ZengHindawi LimitedMediators of Inflammation0962-93511466-18611998-01-017321722010.1080/09629359891162IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous releaseU. Westin0E. Lundberg1K. Ohlsson2Department of Otolaryngology and Head and Neck Surgery, University Hospital of Malmö, University of Lund, Malmö SE-205 02, SwedenDepartment of Surgical Pathophysiology, University Hospital of Malmö, University of Lund, Malmö SE-205 02, SwedenDepartment of Surgical Pathophysiology, University Hospital of Malmö, University of Lund, Malmö SE-205 02, SwedenThe secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study. We found that SLPI inhibited histamine release in a dose-dependent way but was without influence on the spontaneous release.http://dx.doi.org/10.1080/09629359891162SLPIIgEchymasehistaminenasal mucosa.
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	U. Westin E. Lundberg K. Ohlsson
spellingShingle	U. Westin E. Lundberg K. Ohlsson IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release Mediators of Inflammation SLPI IgE chymase histamine nasal mucosa.
author_facet	U. Westin E. Lundberg K. Ohlsson
author_sort	U. Westin
title	IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release
title_short	IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release
title_full	IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release
title_fullStr	IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release
title_full_unstemmed	IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release
title_sort	ige-mediated histamine release from nasal mucosa is inhibited by slpi (secretory leukocyte protease inhibitor) to the level of spontaneous release
publisher	Hindawi Limited
series	Mediators of Inflammation
issn	0962-9351 1466-1861
publishDate	1998-01-01
description	The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study. We found that SLPI inhibited histamine release in a dose-dependent way but was without influence on the spontaneous release.
topic	SLPI IgE chymase histamine nasal mucosa.
url	http://dx.doi.org/10.1080/09629359891162
work_keys_str_mv	AT uwestin igemediatedhistaminereleasefromnasalmucosaisinhibitedbyslpisecretoryleukocyteproteaseinhibitortothelevelofspontaneousrelease AT elundberg igemediatedhistaminereleasefromnasalmucosaisinhibitedbyslpisecretoryleukocyteproteaseinhibitortothelevelofspontaneousrelease AT kohlsson igemediatedhistaminereleasefromnasalmucosaisinhibitedbyslpisecretoryleukocyteproteaseinhibitortothelevelofspontaneousrelease
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IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release

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