Modulation of mRNA expression and activities of xenobiotic metabolizing enzymes, CYP1A1, CYP1A2, CYP2E1, GPx and GSTP1 by the Salicornia freitagii extract in HT-29 human colon cancer cells

Modulation of mRNA expression and activities of xenobiotic metabolizing enzymes, CYP1A1, CYP1A2, CYP2E1, GPx and GSTP1 by the Salicornia freitagii extract in HT-29 human colon cancer cells

Phase I-II detoxification and antioxidant enzymes are responsible for the detoxification and elimination of activated carcinogens, acting as important biomarkers for chemoprevention. Among them, cytochrome P450s plays a prominent role in the metabolic activation of xenobiotics. The herb...

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Bibliographic Details
Main Authors: Altay Ahmet, İrtem Kartal Deniz, Sadi Gökhan, Güray Tülin, Yaprak Ahmet Emre
Format: Article
Language:English
Published: University of Belgrade, University of Novi Sad 2017-01-01
Series:Archives of Biological Sciences
Subjects:
glassworts
cytotoxicity
drug metabolism
colon cancer
phase I-II enzymes
Online Access:http://www.doiserbia.nb.rs/img/doi/0354-4664/2017/0354-46641600118A.pdf

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