Massive pulmonary hemorrhage in enterovirus 71-infected hand, foot, and mouth disease
Hand, foot, and mouth disease (HFMD) is an acute, mostly self-limiting infection. Patients usually recover without any sequelae. However, a few cases are life threatening, especially those caused by enterovirus 71 (EV71). A 12-month-old boy was admitted to a primary hospital with high fever and vesi...
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doaj-6f19cfeb9ec5425e988628d258ce9b692020-11-24T20:58:38ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582015-03-0158311211510.3345/kjp.2015.58.3.1122014600008Massive pulmonary hemorrhage in enterovirus 71-infected hand, foot, and mouth diseaseDong Seong Lee0Young Il Lee1Jeong Bae Ahn2Mi Jin Kim3Jae Hyun Kim4Nam Hee Kim5Jong Hee Hwang6Dong Wook Kim7Chong Guk Lee8Tae Won Song9Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.Division of Vaccine Research, Center for Infectious Disease, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongwon, Korea.Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.Hand, foot, and mouth disease (HFMD) is an acute, mostly self-limiting infection. Patients usually recover without any sequelae. However, a few cases are life threatening, especially those caused by enterovirus 71 (EV71). A 12-month-old boy was admitted to a primary hospital with high fever and vesicular lesions of the mouth, hands, and feet. After 3 days, he experienced 3 seizure episodes and was referred to our hospital. On admission, he was conscious and his chest radiograph was normal. However, 6 hours later, he suddenly lost consciousness and had developed a massive pulmonary hemorrhage that continued until his death. He experienced several more intermittent seizures, and diffuse infiltration of both lung fields was observed on chest radiography. Intravenous immunoglobulin, dexamethasone, cefotaxime, leukocyte-depleted red blood cells, fresh frozen plasma, inotropics, vitamin K, and endotracheal epinephrine were administered. The patient died 9 hours after intubation, within 3 days from fever onset. EV71 subgenotype C4a was isolated retrospectively from serum and nasopharyngeal swab by real-time reverse transcription-polymerase chain reaction. Here, we report a fatal case of EV71-associated HFMD with sudden-onset massive pulmonary hemorrhage and suspected encephalitis.http://kjp.or.kr/upload/pdf/kjped-58-112.pdfEncephalitisEnterovirus 71Hand, foot, and mouth diseasePulmonary hemorrhage |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dong Seong Lee Young Il Lee Jeong Bae Ahn Mi Jin Kim Jae Hyun Kim Nam Hee Kim Jong Hee Hwang Dong Wook Kim Chong Guk Lee Tae Won Song |
spellingShingle |
Dong Seong Lee Young Il Lee Jeong Bae Ahn Mi Jin Kim Jae Hyun Kim Nam Hee Kim Jong Hee Hwang Dong Wook Kim Chong Guk Lee Tae Won Song Massive pulmonary hemorrhage in enterovirus 71-infected hand, foot, and mouth disease Korean Journal of Pediatrics Encephalitis Enterovirus 71 Hand, foot, and mouth disease Pulmonary hemorrhage |
author_facet |
Dong Seong Lee Young Il Lee Jeong Bae Ahn Mi Jin Kim Jae Hyun Kim Nam Hee Kim Jong Hee Hwang Dong Wook Kim Chong Guk Lee Tae Won Song |
author_sort |
Dong Seong Lee |
title |
Massive pulmonary hemorrhage in enterovirus 71-infected hand, foot, and mouth disease |
title_short |
Massive pulmonary hemorrhage in enterovirus 71-infected hand, foot, and mouth disease |
title_full |
Massive pulmonary hemorrhage in enterovirus 71-infected hand, foot, and mouth disease |
title_fullStr |
Massive pulmonary hemorrhage in enterovirus 71-infected hand, foot, and mouth disease |
title_full_unstemmed |
Massive pulmonary hemorrhage in enterovirus 71-infected hand, foot, and mouth disease |
title_sort |
massive pulmonary hemorrhage in enterovirus 71-infected hand, foot, and mouth disease |
publisher |
Korean Pediatric Society |
series |
Korean Journal of Pediatrics |
issn |
1738-1061 2092-7258 |
publishDate |
2015-03-01 |
description |
Hand, foot, and mouth disease (HFMD) is an acute, mostly self-limiting infection. Patients usually recover without any sequelae. However, a few cases are life threatening, especially those caused by enterovirus 71 (EV71). A 12-month-old boy was admitted to a primary hospital with high fever and vesicular lesions of the mouth, hands, and feet. After 3 days, he experienced 3 seizure episodes and was referred to our hospital. On admission, he was conscious and his chest radiograph was normal. However, 6 hours later, he suddenly lost consciousness and had developed a massive pulmonary hemorrhage that continued until his death. He experienced several more intermittent seizures, and diffuse infiltration of both lung fields was observed on chest radiography. Intravenous immunoglobulin, dexamethasone, cefotaxime, leukocyte-depleted red blood cells, fresh frozen plasma, inotropics, vitamin K, and endotracheal epinephrine were administered. The patient died 9 hours after intubation, within 3 days from fever onset. EV71 subgenotype C4a was isolated retrospectively from serum and nasopharyngeal swab by real-time reverse transcription-polymerase chain reaction. Here, we report a fatal case of EV71-associated HFMD with sudden-onset massive pulmonary hemorrhage and suspected encephalitis. |
topic |
Encephalitis Enterovirus 71 Hand, foot, and mouth disease Pulmonary hemorrhage |
url |
http://kjp.or.kr/upload/pdf/kjped-58-112.pdf |
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