Progress of immunotherapy of anti-α-synuclein in Parkinson’s disease

• Main Authors: Zhipeng Wang, Ge Gao, Chunli Duan, Hui Yang
• Format: Article
• Language: English
• Published: Elsevier 2019-07-01
• Series: Biomedicine & Pharmacotherapy
• Subjects: Parkinson’s disease; α-Synuclein; Immunotherapy; Monoclonal antibody
• Online Access: http://www.sciencedirect.com/science/article/pii/S0753332218377989

Many neurodegenerative diseases are characterized by progressive loss of neurons and abnormal protein accumulation, including amyloid (A)β and tau in Alzheimer’s disease and Lewy bodies and α-synuclein (α-syn) in Parkinson’s disease (PD). Recent evidence suggests that adaptive immunity plays an important role in PD, and that anti-α-syn antibodies can be used as therapy in neurodegenerative diseases; monoclonal antibodies were shown to inhibit α-syn propagation and aggregation in PD models and patients. In this review, we summarize the different pathological states of α-syn, including gene mutations, truncation, phosphorylation, and the high molecular weight form, and describe the specific antibodies that recognize the α-syn monomer or oligomer, some of which have been tested in clinic trials. We also discuss future research directions and potential targets in PD therapy.