PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation

PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation

Contrast-induced acute kidney injury (CI-AKI) occurs in more than 30% of patients after intravenous iodinated contrast media and causes serious complications, including renal failure and mortality. Recent research has demonstrated that routine antioxidant and alkaline therapy failed to show benefits...

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Bibliographic Details
Main Authors: Qisheng Lin, Shu Li, Na Jiang, Xinghua Shao, Minfang Zhang, Haijiao Jin, Zhen Zhang, Jianxiao Shen, Yijun Zhou, Wenyan Zhou, Leyi Gu, Renhua Lu, Zhaohui Ni
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231719302988

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