Heparanase induces necroptosis of microvascular endothelial cells to promote the metastasis of hepatocellular carcinoma
Abstract Heparanase (HPSE) is a kind of multifunctional extracellular hydrolase, and related to metastasis of hepatocellular carcinoma (HCC). Endothelial necroptosis promotes the metastasis of cancer cells. It is not clear whether HPSE could mediate necroptosis of microvascular endothelial cells (MV...
Main Authors: | Xiaopeng Chen, Bin Cheng, Dafei Dai, Yuhai Wu, Zhiwen Feng, Chaogang Tong, Xiangming Wang, Jun Zhao |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-02-01
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Series: | Cell Death Discovery |
Online Access: | https://doi.org/10.1038/s41420-021-00411-5 |
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