Extracellular Vesicles in Liquid Biopsies: Potential for Disease Diagnosis

Liquid biopsy is conducted through minimally invasive or noninvasive procedures, and the resulting material can be subjected to genomic, proteomic, and lipidomic analyses for early diagnosis of cancers and other diseases. Extracellular vesicles (EVs), one kind of promising tool for liquid biopsy, ar...

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Main Authors:	Jialing Liu, Ye Chen, Fang Pei, Chongmai Zeng, Yang Yao, Wen Liao, Zhihe Zhao
Format:	Article
Language:	English
Published:	Hindawi Limited 2021-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2021/6611244

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spelling	doaj-6f2411b857d84b568e8e27fc8a74ea302021-02-15T12:52:45ZengHindawi LimitedBioMed Research International2314-61332314-61412021-01-01202110.1155/2021/66112446611244Extracellular Vesicles in Liquid Biopsies: Potential for Disease DiagnosisJialing Liu0Ye Chen1Fang Pei2Chongmai Zeng3Yang Yao4Wen Liao5Zhihe Zhao6Department of Orthodontics, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, ChinaDepartment of Orthodontics, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, ChinaDepartment of Orthodontics, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, ChinaDepartment of Orthodontics, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, ChinaDepartment of Implantology, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, ChinaDepartment of Orthodontics, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, ChinaDepartment of Orthodontics, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, ChinaLiquid biopsy is conducted through minimally invasive or noninvasive procedures, and the resulting material can be subjected to genomic, proteomic, and lipidomic analyses for early diagnosis of cancers and other diseases. Extracellular vesicles (EVs), one kind of promising tool for liquid biopsy, are nanosized bilayer particles that are secreted by all kinds of cells and that carry cargoes such as lipids, proteins, and nucleic acids, protecting them from enzymatic degradation in the extracellular environment. In this review, we provide a comprehensive introduction to the properties and applications of EVs, including their biogenesis, contents, sample collection, isolation, and applications in diagnostics based on liquid biopsy.http://dx.doi.org/10.1155/2021/6611244
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jialing Liu Ye Chen Fang Pei Chongmai Zeng Yang Yao Wen Liao Zhihe Zhao
spellingShingle	Jialing Liu Ye Chen Fang Pei Chongmai Zeng Yang Yao Wen Liao Zhihe Zhao Extracellular Vesicles in Liquid Biopsies: Potential for Disease Diagnosis BioMed Research International
author_facet	Jialing Liu Ye Chen Fang Pei Chongmai Zeng Yang Yao Wen Liao Zhihe Zhao
author_sort	Jialing Liu
title	Extracellular Vesicles in Liquid Biopsies: Potential for Disease Diagnosis
title_short	Extracellular Vesicles in Liquid Biopsies: Potential for Disease Diagnosis
title_full	Extracellular Vesicles in Liquid Biopsies: Potential for Disease Diagnosis
title_fullStr	Extracellular Vesicles in Liquid Biopsies: Potential for Disease Diagnosis
title_full_unstemmed	Extracellular Vesicles in Liquid Biopsies: Potential for Disease Diagnosis
title_sort	extracellular vesicles in liquid biopsies: potential for disease diagnosis
publisher	Hindawi Limited
series	BioMed Research International
issn	2314-6133 2314-6141
publishDate	2021-01-01
description	Liquid biopsy is conducted through minimally invasive or noninvasive procedures, and the resulting material can be subjected to genomic, proteomic, and lipidomic analyses for early diagnosis of cancers and other diseases. Extracellular vesicles (EVs), one kind of promising tool for liquid biopsy, are nanosized bilayer particles that are secreted by all kinds of cells and that carry cargoes such as lipids, proteins, and nucleic acids, protecting them from enzymatic degradation in the extracellular environment. In this review, we provide a comprehensive introduction to the properties and applications of EVs, including their biogenesis, contents, sample collection, isolation, and applications in diagnostics based on liquid biopsy.
url	http://dx.doi.org/10.1155/2021/6611244
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Extracellular Vesicles in Liquid Biopsies: Potential for Disease Diagnosis

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