Platinum Complexes Can Bind to Telomeres by Coordination

Platinum Complexes Can Bind to Telomeres by Coordination

It is suggested that several compounds, including G-quadruplex ligands, can target telomeres, inducing their uncapping and, ultimately, cell death. However, it has never been demonstrated whether such ligands can bind directly and quantitatively to telomeres. Here, we employed the property of platin...

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Bibliographic Details
Main Authors: Lina Saker, Samar Ali, Caroline Masserot, Guillaume Kellermann, Joel Poupon, Marie-Paule Teulade-Fichou, Evelyne Ségal-Bendirdjian, Sophie Bombard
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
telomeres
platinum complexes
cisplatin
G-quadruplex
TRF2
Online Access:http://www.mdpi.com/1422-0067/19/7/1951

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