Inflammatory response to acute exposure to welding fumes during the working day
Objectives: To investigate cardiorespiratory and inflammatory responses in male workers following exposure to welding fumes and airborne particles in actual workplace conditions. Materials and Methods: We measured blood leukocytes and their differential counts, platelet count, hemoglobin, sensitive...
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Nofer Institute of Occupational Medicine
2013-04-01
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doaj-6f2cd1c87e334a1e90d566be8e8316cb2020-11-24T22:49:47ZengNofer Institute of Occupational MedicineInternational Journal of Occupational Medicine and Environmental Health1232-10871896-494X2013-04-0126222022910.2478/s13382-013-0097-zInflammatory response to acute exposure to welding fumes during the working dayMerja JärveläPaula KauppiTimo TuomiRitva LuukkonenHarri LindholmRiina NieminenEeva MoilanenTimo HannuObjectives: To investigate cardiorespiratory and inflammatory responses in male workers following exposure to welding fumes and airborne particles in actual workplace conditions. Materials and Methods: We measured blood leukocytes and their differential counts, platelet count, hemoglobin, sensitive C-reactive protein, fibrinogen, E-selectin, IL-(interleukin)1β, IL-6, IL-8, tumor necrosis factor alpha (TNF-α) and endothelin-1 in blood samples of twenty workers before and after their working day. We also studied peak expiratory flow (PEF), forced expiratory volume in one second (FEV1), and exhaled nitric oxide (NO). We assessed heart rate variability (HRV) by obtaining 24-hour ambulatory electrocardiograms. Results: The total blood leukocytes and neutrophils increased after the work shift, whereas IL-1β and E-selectin decreased significantly. There were no tatistically significant changes in exhaled NO, FEV1, PEF or HRV. Conclusion: Occupational exposure to welding fumes and particles caused a slight, acute inflammatory effect estimated based on the increased values of leukocytes and neutrophils in blood and a decrease in the interleukin 1β and E-selectin values, but no changes in the pulmonary function (exhaled NO, FEV1, PEF) or HRV during the working day were observed.http://ijomeh.eu/Inflammatory-response-to-acute-exposure-to-welding-fumes-during-the-working-day,2199,0,2.htmlCytokinesE-selectinExhaled Nitric Oxide (NO)heart rate variability (HRV)interleukin-1βwelding |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Merja Järvelä Paula Kauppi Timo Tuomi Ritva Luukkonen Harri Lindholm Riina Nieminen Eeva Moilanen Timo Hannu |
spellingShingle |
Merja Järvelä Paula Kauppi Timo Tuomi Ritva Luukkonen Harri Lindholm Riina Nieminen Eeva Moilanen Timo Hannu Inflammatory response to acute exposure to welding fumes during the working day International Journal of Occupational Medicine and Environmental Health Cytokines E-selectin Exhaled Nitric Oxide (NO) heart rate variability (HRV) interleukin-1β welding |
author_facet |
Merja Järvelä Paula Kauppi Timo Tuomi Ritva Luukkonen Harri Lindholm Riina Nieminen Eeva Moilanen Timo Hannu |
author_sort |
Merja Järvelä |
title |
Inflammatory response to acute exposure to welding fumes during the working day |
title_short |
Inflammatory response to acute exposure to welding fumes during the working day |
title_full |
Inflammatory response to acute exposure to welding fumes during the working day |
title_fullStr |
Inflammatory response to acute exposure to welding fumes during the working day |
title_full_unstemmed |
Inflammatory response to acute exposure to welding fumes during the working day |
title_sort |
inflammatory response to acute exposure to welding fumes during the working day |
publisher |
Nofer Institute of Occupational Medicine |
series |
International Journal of Occupational Medicine and Environmental Health |
issn |
1232-1087 1896-494X |
publishDate |
2013-04-01 |
description |
Objectives: To investigate cardiorespiratory and inflammatory responses in male workers following exposure to welding fumes and airborne particles in actual workplace conditions. Materials and Methods: We measured blood leukocytes and their differential counts, platelet count, hemoglobin, sensitive C-reactive protein, fibrinogen, E-selectin, IL-(interleukin)1β, IL-6, IL-8, tumor necrosis factor alpha (TNF-α) and endothelin-1 in blood samples of twenty workers before and after their working day. We also studied peak expiratory flow (PEF), forced expiratory volume in one second (FEV1), and exhaled nitric oxide (NO). We assessed heart rate variability (HRV) by obtaining 24-hour ambulatory electrocardiograms. Results: The total blood leukocytes and neutrophils increased after the work shift, whereas IL-1β and E-selectin decreased significantly. There were no tatistically significant changes in exhaled NO, FEV1, PEF or HRV. Conclusion: Occupational exposure to welding fumes and particles caused a slight, acute inflammatory effect estimated based on the increased values of leukocytes and neutrophils in blood and a decrease in the interleukin 1β and E-selectin values, but no changes in the pulmonary function (exhaled NO, FEV1, PEF) or HRV during the working day were observed. |
topic |
Cytokines E-selectin Exhaled Nitric Oxide (NO) heart rate variability (HRV) interleukin-1β welding |
url |
http://ijomeh.eu/Inflammatory-response-to-acute-exposure-to-welding-fumes-during-the-working-day,2199,0,2.html |
work_keys_str_mv |
AT merjajarvela inflammatoryresponsetoacuteexposuretoweldingfumesduringtheworkingday AT paulakauppi inflammatoryresponsetoacuteexposuretoweldingfumesduringtheworkingday AT timotuomi inflammatoryresponsetoacuteexposuretoweldingfumesduringtheworkingday AT ritvaluukkonen inflammatoryresponsetoacuteexposuretoweldingfumesduringtheworkingday AT harrilindholm inflammatoryresponsetoacuteexposuretoweldingfumesduringtheworkingday AT riinanieminen inflammatoryresponsetoacuteexposuretoweldingfumesduringtheworkingday AT eevamoilanen inflammatoryresponsetoacuteexposuretoweldingfumesduringtheworkingday AT timohannu inflammatoryresponsetoacuteexposuretoweldingfumesduringtheworkingday |
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