Anthocyanin supplementation inhibits secretion of pro-inflammatory cytokines in overweight and obese individuals

• Main Authors: Lada Vugic, Natalie Colson, Elham Nikbakht, Almottesembellah Gaiz, Olivia J. Holland, Avinash Reddy Kundur, Indu Singh
• Format: Article
• Language: English
• Published: Elsevier 2020-01-01
• Series: Journal of Functional Foods
• Subjects: Anthocyanins; TNF-α; IL-6; CCL2; Chronic inflammation; Obesity
• Online Access: http://www.sciencedirect.com/science/article/pii/S1756464619305201

Chronic low-grade inflammation in obese and overweight individuals is associated with an increased risk of type II diabetes and cardiovascular disease. The current trial investigated the anti-inflammatory properties of anthocyanin (ACN) supplementation in lean, overweight and obese individuals. Fifteen lean, ten overweight and ten obese participants consumed ACN (320 mg/day) for 28 days along with their usual diet. ACN supplementation significantly decreased blood plasma levels of CCL2 in the lean, overweight and obese groups (p < 0.0001, p < 0.0001 and p < 0.01 respectively). Additionally, significantly decreased levels of IL-6 in the obese group (p < 0.05) were also observed post-ACN supplementation. In conclusion, these results demonstrate the anti-inflammatory potential of ACN and suggest the supplementation of ACN as a complementary therapeutic agent for reducing chronic inflammation in obese and overweight individuals.