Synthesis of New Triazolopyrazine Antimalarial Compounds

Synthesis of New Triazolopyrazine Antimalarial Compounds

A radical approach to late-stage functionalization using photoredox and Diversinate<sup>™</sup> chemistry on the Open Source Malaria (OSM) triazolopyrazine scaffold (Series 4) resulted in the synthesis of 12 new analogues, which were characterized by NMR, UV, and MS data analysis. The st...

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Bibliographic Details
Main Authors: Daniel J. G. Johnson, Ian D. Jenkins, Cohan Huxley, Mark J. Coster, Kah Yean Lum, Jonathan M. White, Vicky M. Avery, Rohan A. Davis
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
Open Source Malaria
drug discovery
synthesis
triazolopyrazine
late-stage functionalization
photoredox
Online Access:https://www.mdpi.com/1420-3049/26/9/2421

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