Aging of mesenchymal stem cells: Implication in regenerative medicine
Multipotent mesenchymal stem cells (MSCs) represent a great candidate for various clinical applications including regenerative medicine. However, aging both in vivo and in vitro can significantly compromise MSC characteristics and performance. This paper highlights current thoughts on senescence-ind...
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Elsevier
2018-12-01
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| Series: | Regenerative Therapy |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S235232041830035X |
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doaj-6f46debd27e8466ea4a9baf0322df9262020-11-24T23:01:14ZengElsevierRegenerative Therapy2352-32042018-12-019120122Aging of mesenchymal stem cells: Implication in regenerative medicineYueh-Hsun Kevin Yang0Grove School of Engineering, The City University of New York – the City College, 160 Convent Avenue, Steinman Hall 581, New York, NY 10031, USA. Fax: +1 212 6505768.; Grove School of Engineering, The City University of New York – the City College, New York, NY 10031, USAMultipotent mesenchymal stem cells (MSCs) represent a great candidate for various clinical applications including regenerative medicine. However, aging both in vivo and in vitro can significantly compromise MSC characteristics and performance. This paper highlights current thoughts on senescence-induced damage to MSCs that should be considered prior to their use for regeneration of different cells, tissues or organs. Keywords: Mesenchymal stem cell, Aging, Senescence, Regenerative medicine, Proliferation, Differentiationhttp://www.sciencedirect.com/science/article/pii/S235232041830035X |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yueh-Hsun Kevin Yang |
| spellingShingle |
Yueh-Hsun Kevin Yang Aging of mesenchymal stem cells: Implication in regenerative medicine Regenerative Therapy |
| author_facet |
Yueh-Hsun Kevin Yang |
| author_sort |
Yueh-Hsun Kevin Yang |
| title |
Aging of mesenchymal stem cells: Implication in regenerative medicine |
| title_short |
Aging of mesenchymal stem cells: Implication in regenerative medicine |
| title_full |
Aging of mesenchymal stem cells: Implication in regenerative medicine |
| title_fullStr |
Aging of mesenchymal stem cells: Implication in regenerative medicine |
| title_full_unstemmed |
Aging of mesenchymal stem cells: Implication in regenerative medicine |
| title_sort |
aging of mesenchymal stem cells: implication in regenerative medicine |
| publisher |
Elsevier |
| series |
Regenerative Therapy |
| issn |
2352-3204 |
| publishDate |
2018-12-01 |
| description |
Multipotent mesenchymal stem cells (MSCs) represent a great candidate for various clinical applications including regenerative medicine. However, aging both in vivo and in vitro can significantly compromise MSC characteristics and performance. This paper highlights current thoughts on senescence-induced damage to MSCs that should be considered prior to their use for regeneration of different cells, tissues or organs. Keywords: Mesenchymal stem cell, Aging, Senescence, Regenerative medicine, Proliferation, Differentiation |
| url |
http://www.sciencedirect.com/science/article/pii/S235232041830035X |
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AT yuehhsunkevinyang agingofmesenchymalstemcellsimplicationinregenerativemedicine |
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