Hypercalcaemia: A portent of sarcoidosis in cystic fibrosis
The coexistence of cystic fibrosis (CF) and sarcoidosis is rare. We report a 22-year-old male cystic fibrosis patient who presented multiple times to the Sultan Qaboos University Hospital, Muscat, Oman, in 2013. He was diagnosed with non-parathyroid-related hypercalcaemia and anterior uveitis, while...
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doaj-6f5a00efb3c14e59bca82aece9a6e6c62020-11-25T03:04:35ZengSultan Qaboos UniversitySultan Qaboos University Medical Journal 2075-051X2075-05282019-03-0118453353610.18295/squmj.2018.18.04.0182538Hypercalcaemia: A portent of sarcoidosis in cystic fibrosisJayakrishnan B.0Saif M. Al-Mubaihsi1Masoud S. Kashoub2Jojy George3Department of Medicine, Sultan Qaboos University Hospital, Muscat, OmanDepartment of Medicine, Sultan Qaboos University Hospital, Muscat, OmanDepartment of Medicine, Sultan Qaboos University Hospital, Muscat, OmanDepartment of Medicine, Sultan Qaboos University Hospital, Muscat, OmanThe coexistence of cystic fibrosis (CF) and sarcoidosis is rare. We report a 22-year-old male cystic fibrosis patient who presented multiple times to the Sultan Qaboos University Hospital, Muscat, Oman, in 2013. He was diagnosed with non-parathyroid-related hypercalcaemia and anterior uveitis, while computed tomography revealed mediastinal and abdominal lymphadenopathy and mild hepatosplenomegaly. These findings, in addition to the presence of calciuria and a high angiotensin-converting enzyme (ACE) level, confirmed a clinical diagnosis of sarcoidosis. The patient responded well to treatment with oral prednisolone which, over the course of two years, resulted in the near-complete resolution of parenchymal nodular infiltrates, regression of hilar lymphadenopathy, resolution of hypercalcaemia and the normalisation of his ACE levels. Diagnosing pulmonary sarcoidosis in CF can be challenging as most adult patients already have extensive lung disease. Physicians should be aware that hypercalcaemia may be an early manifestation of sarcoidosis in such cases. Keywords: Sarcoidosis; Cystic Fibrosis; Hypercalcemia; Case Report; Oman.https://journals.squ.edu.om/index.php/squmj/article/view/2999 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jayakrishnan B. Saif M. Al-Mubaihsi Masoud S. Kashoub Jojy George |
spellingShingle |
Jayakrishnan B. Saif M. Al-Mubaihsi Masoud S. Kashoub Jojy George Hypercalcaemia: A portent of sarcoidosis in cystic fibrosis Sultan Qaboos University Medical Journal |
author_facet |
Jayakrishnan B. Saif M. Al-Mubaihsi Masoud S. Kashoub Jojy George |
author_sort |
Jayakrishnan B. |
title |
Hypercalcaemia: A portent of sarcoidosis in cystic fibrosis |
title_short |
Hypercalcaemia: A portent of sarcoidosis in cystic fibrosis |
title_full |
Hypercalcaemia: A portent of sarcoidosis in cystic fibrosis |
title_fullStr |
Hypercalcaemia: A portent of sarcoidosis in cystic fibrosis |
title_full_unstemmed |
Hypercalcaemia: A portent of sarcoidosis in cystic fibrosis |
title_sort |
hypercalcaemia: a portent of sarcoidosis in cystic fibrosis |
publisher |
Sultan Qaboos University |
series |
Sultan Qaboos University Medical Journal |
issn |
2075-051X 2075-0528 |
publishDate |
2019-03-01 |
description |
The coexistence of cystic fibrosis (CF) and sarcoidosis is rare. We report a 22-year-old male cystic fibrosis patient who presented multiple times to the Sultan Qaboos University Hospital, Muscat, Oman, in 2013. He was diagnosed with non-parathyroid-related hypercalcaemia and anterior uveitis, while computed tomography revealed mediastinal and abdominal lymphadenopathy and mild hepatosplenomegaly. These findings, in addition to the presence of calciuria and a high angiotensin-converting enzyme (ACE) level, confirmed a clinical diagnosis of sarcoidosis. The patient responded well to treatment with oral prednisolone which, over the course of two years, resulted in the near-complete resolution of parenchymal nodular infiltrates, regression of hilar lymphadenopathy, resolution of hypercalcaemia and the normalisation of his ACE levels. Diagnosing pulmonary sarcoidosis in CF can be challenging as most adult patients already have extensive lung disease. Physicians should be aware that hypercalcaemia may be an early manifestation of sarcoidosis in such cases.
Keywords: Sarcoidosis; Cystic Fibrosis; Hypercalcemia; Case Report; Oman. |
url |
https://journals.squ.edu.om/index.php/squmj/article/view/2999 |
work_keys_str_mv |
AT jayakrishnanb hypercalcaemiaaportentofsarcoidosisincysticfibrosis AT saifmalmubaihsi hypercalcaemiaaportentofsarcoidosisincysticfibrosis AT masoudskashoub hypercalcaemiaaportentofsarcoidosisincysticfibrosis AT jojygeorge hypercalcaemiaaportentofsarcoidosisincysticfibrosis |
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