The Impact of Single Session Intermittent Theta-Burst Stimulation over the Dorsolateral Prefrontal Cortex and Posterior Superior Temporal Sulcus on Adults with Autism Spectrum Disorder
Intermittent theta burst stimulation (iTBS), a patterned repetitive transcranial magnetic stimulation, was applied over the posterior superior temporal sulcus (pSTS) or dorsolateral prefrontal cortex (DLPFC) to explore its impact in adults with autism spectrum disorder (ASD). Among 25 adults with AS...
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doaj-6f5a3add619a47ef9082273fb9d0712b2020-11-24T23:14:53ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2017-05-011110.3389/fnins.2017.00255252511The Impact of Single Session Intermittent Theta-Burst Stimulation over the Dorsolateral Prefrontal Cortex and Posterior Superior Temporal Sulcus on Adults with Autism Spectrum DisorderHsing-Chang Ni0Hsing-Chang Ni1June Hung2Chen-Te Wu3Yu-Yu Wu4Chee-Jen Chang5Chee-Jen Chang6Chee-Jen Chang7Rou-Shayn Chen8Ying-Zu Huang9Ying-Zu Huang10Ying-Zu Huang11Department of Psychiatry, Chang Gung Memorial Hospital at LinkouLinkou, TaiwanGraduate Institute of Clinical Medicine, National Taiwan University College of MedicineTaipei, TaiwanDepartment of Neurology, Neuroscience Research Center, Chang Gung Memorial Hospital at LinkouTaipei, TaiwanDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital at LinkouTaipei, TaiwanDepartment of Psychiatry, Chang Gung Memorial Hospital at LinkouLinkou, TaiwanGraduate Institute of Clinical Medical Science, Chang Gung UniversityTaoyuan, TaiwanClinical Informatics and Medical Statistics Research Center, Chang Gung UniversityTaoyuan, TaiwanResearch Services Center for Health Information, Chang Gung UniversityTaoyuan, TaiwanDepartment of Neurology, Neuroscience Research Center, Chang Gung Memorial Hospital at LinkouTaipei, TaiwanDepartment of Neurology, Neuroscience Research Center, Chang Gung Memorial Hospital at LinkouTaipei, TaiwanMedical School, Chang Gung UniversityTaoyuan, TaiwanInstitute of Cognitive Neuroscience, National Central UniversityTaoyuan, TaiwanIntermittent theta burst stimulation (iTBS), a patterned repetitive transcranial magnetic stimulation, was applied over the posterior superior temporal sulcus (pSTS) or dorsolateral prefrontal cortex (DLPFC) to explore its impact in adults with autism spectrum disorder (ASD). Among 25 adults with ASD, 19 (mean age: 20.8 years) completed the randomized, sham-controlled, crossover trial. Every participant received iTBS over the bilateral DLPFC, bilateral pSTS and inion (as a sham control stimulation) in a randomized order with a 1-week interval. Neuropsychological functions were assessed using the Conners' Continuous Performance Test (CCPT) and the Wisconsin Card Sorting Test (WCST). Behavioral outcomes were measured using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and the Social Responsiveness Scale (SRS). In comparison to that in the sham stimulation, the reaction time in the CCPT significantly decreased following single DLPFC session (p = 0.04, effect size = 0.71) while there were no significant differences in the CCPT and WCST following single pSTS session. Besides, the results in behavioral outcomes were inconsistent and had discrepancy between reports of parents and patients. In conclusion, a single session of iTBS over the bilateral DLPFC may alter the neuropsychological function in adults with ASD. The impacts of multiple-sessions iTBS over the DLPFC or pSTS deserve further investigations.http://journal.frontiersin.org/article/10.3389/fnins.2017.00255/fullrepetitive transcranial magnetic stimulationtheta burst stimulationdorsolateral prefrontal cortexposterior superior temporal sulcusautism spectrum disorder |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hsing-Chang Ni Hsing-Chang Ni June Hung Chen-Te Wu Yu-Yu Wu Chee-Jen Chang Chee-Jen Chang Chee-Jen Chang Rou-Shayn Chen Ying-Zu Huang Ying-Zu Huang Ying-Zu Huang |
spellingShingle |
Hsing-Chang Ni Hsing-Chang Ni June Hung Chen-Te Wu Yu-Yu Wu Chee-Jen Chang Chee-Jen Chang Chee-Jen Chang Rou-Shayn Chen Ying-Zu Huang Ying-Zu Huang Ying-Zu Huang The Impact of Single Session Intermittent Theta-Burst Stimulation over the Dorsolateral Prefrontal Cortex and Posterior Superior Temporal Sulcus on Adults with Autism Spectrum Disorder Frontiers in Neuroscience repetitive transcranial magnetic stimulation theta burst stimulation dorsolateral prefrontal cortex posterior superior temporal sulcus autism spectrum disorder |
author_facet |
Hsing-Chang Ni Hsing-Chang Ni June Hung Chen-Te Wu Yu-Yu Wu Chee-Jen Chang Chee-Jen Chang Chee-Jen Chang Rou-Shayn Chen Ying-Zu Huang Ying-Zu Huang Ying-Zu Huang |
author_sort |
Hsing-Chang Ni |
title |
The Impact of Single Session Intermittent Theta-Burst Stimulation over the Dorsolateral Prefrontal Cortex and Posterior Superior Temporal Sulcus on Adults with Autism Spectrum Disorder |
title_short |
The Impact of Single Session Intermittent Theta-Burst Stimulation over the Dorsolateral Prefrontal Cortex and Posterior Superior Temporal Sulcus on Adults with Autism Spectrum Disorder |
title_full |
The Impact of Single Session Intermittent Theta-Burst Stimulation over the Dorsolateral Prefrontal Cortex and Posterior Superior Temporal Sulcus on Adults with Autism Spectrum Disorder |
title_fullStr |
The Impact of Single Session Intermittent Theta-Burst Stimulation over the Dorsolateral Prefrontal Cortex and Posterior Superior Temporal Sulcus on Adults with Autism Spectrum Disorder |
title_full_unstemmed |
The Impact of Single Session Intermittent Theta-Burst Stimulation over the Dorsolateral Prefrontal Cortex and Posterior Superior Temporal Sulcus on Adults with Autism Spectrum Disorder |
title_sort |
impact of single session intermittent theta-burst stimulation over the dorsolateral prefrontal cortex and posterior superior temporal sulcus on adults with autism spectrum disorder |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2017-05-01 |
description |
Intermittent theta burst stimulation (iTBS), a patterned repetitive transcranial magnetic stimulation, was applied over the posterior superior temporal sulcus (pSTS) or dorsolateral prefrontal cortex (DLPFC) to explore its impact in adults with autism spectrum disorder (ASD). Among 25 adults with ASD, 19 (mean age: 20.8 years) completed the randomized, sham-controlled, crossover trial. Every participant received iTBS over the bilateral DLPFC, bilateral pSTS and inion (as a sham control stimulation) in a randomized order with a 1-week interval. Neuropsychological functions were assessed using the Conners' Continuous Performance Test (CCPT) and the Wisconsin Card Sorting Test (WCST). Behavioral outcomes were measured using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and the Social Responsiveness Scale (SRS). In comparison to that in the sham stimulation, the reaction time in the CCPT significantly decreased following single DLPFC session (p = 0.04, effect size = 0.71) while there were no significant differences in the CCPT and WCST following single pSTS session. Besides, the results in behavioral outcomes were inconsistent and had discrepancy between reports of parents and patients. In conclusion, a single session of iTBS over the bilateral DLPFC may alter the neuropsychological function in adults with ASD. The impacts of multiple-sessions iTBS over the DLPFC or pSTS deserve further investigations. |
topic |
repetitive transcranial magnetic stimulation theta burst stimulation dorsolateral prefrontal cortex posterior superior temporal sulcus autism spectrum disorder |
url |
http://journal.frontiersin.org/article/10.3389/fnins.2017.00255/full |
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