Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary
Abstract Background The burden of sickle cell disease (SCD) is greatest among African nations. Effective scalability of evidence-based interventions (e.g., newborn screening, health education, prophylaxis for infection, optimal nutrition and hydration, hydroxyurea therapy, blood transfusions, and tr...
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doaj-6f5edf7dd2084769bf163da0aadc348f2021-02-21T12:45:21ZengBMCGlobalization and Health1744-86032021-02-011711410.1186/s12992-021-00671-xImplementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentaryJoyce Gyamfi0Temitope Ojo1Juliet Iwelunmor2Gbenga Ogedegbe3Nessa Ryan4Amy Diawara5Obiageli Nnodu6Ambroise Wonkam7Charmaine Royal8Emmanuel Peprah9Global Health Program and Department of Social and Behavioral Sciences, NYU School of Global Public HealthGlobal Health Program and Department of Social and Behavioral Sciences, NYU School of Global Public HealthBehavioral Science and Health Education, College for Public Health and Social Justice, Salus Center, Saint Louis UniversityDepartment of Population Health, NYU School of Medicine, NYU Langone HealthGlobal Health Program and Department of Social and Behavioral Sciences, NYU School of Global Public HealthGlobal Health Program and Department of Social and Behavioral Sciences, NYU School of Global Public HealthCentre of Excellence for Sickle Cell Disease Research & Training (CESRTA), University of Abuja, Airport - Giri ExpresswayDivision of Human Genetics, Faculty of Health Sciences - University of Cape TownDepartments of African & African American Studies, Biology, Global Health, and Family Medicine & Community Health, Duke UniversityGlobal Health Program and Department of Social and Behavioral Sciences, NYU School of Global Public HealthAbstract Background The burden of sickle cell disease (SCD) is greatest among African nations. Effective scalability of evidence-based interventions (e.g., newborn screening, health education, prophylaxis for infection, optimal nutrition and hydration, hydroxyurea therapy, blood transfusions, and transcranial Doppler (TCD) screening) is urgently needed particularly in these settings for disease management. However, Africa is constrained by limited resources and the lack of capacity to conduct implementation science research for proper understanding of context, and assessment of barriers and facilitators to the uptake and scalability of evidence-based interventions (EBI) for SCD management. Main Body We outline implementation science approaches to embed EBI for SCD within the African context and highlight key implementation research programs for SCD management. Building implementation research capacity will meet the major need of developing effective life-long and accessible locally-tailored interventions for patients with SCD in Africa. Conclusion This commentary communicates the importance of the application of implementation science methodology to scale-up evidence-based interventions for the management of SCD in order to reduce pain, prevent other morbidities and premature death experienced by people with SCD in Africa, and improve their overall quality of life.https://doi.org/10.1186/s12992-021-00671-xGlobal healthImplementation science researchSickle cell diseaseAfricaScale-up |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Joyce Gyamfi Temitope Ojo Juliet Iwelunmor Gbenga Ogedegbe Nessa Ryan Amy Diawara Obiageli Nnodu Ambroise Wonkam Charmaine Royal Emmanuel Peprah |
spellingShingle |
Joyce Gyamfi Temitope Ojo Juliet Iwelunmor Gbenga Ogedegbe Nessa Ryan Amy Diawara Obiageli Nnodu Ambroise Wonkam Charmaine Royal Emmanuel Peprah Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary Globalization and Health Global health Implementation science research Sickle cell disease Africa Scale-up |
author_facet |
Joyce Gyamfi Temitope Ojo Juliet Iwelunmor Gbenga Ogedegbe Nessa Ryan Amy Diawara Obiageli Nnodu Ambroise Wonkam Charmaine Royal Emmanuel Peprah |
author_sort |
Joyce Gyamfi |
title |
Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary |
title_short |
Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary |
title_full |
Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary |
title_fullStr |
Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary |
title_full_unstemmed |
Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary |
title_sort |
implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary |
publisher |
BMC |
series |
Globalization and Health |
issn |
1744-8603 |
publishDate |
2021-02-01 |
description |
Abstract Background The burden of sickle cell disease (SCD) is greatest among African nations. Effective scalability of evidence-based interventions (e.g., newborn screening, health education, prophylaxis for infection, optimal nutrition and hydration, hydroxyurea therapy, blood transfusions, and transcranial Doppler (TCD) screening) is urgently needed particularly in these settings for disease management. However, Africa is constrained by limited resources and the lack of capacity to conduct implementation science research for proper understanding of context, and assessment of barriers and facilitators to the uptake and scalability of evidence-based interventions (EBI) for SCD management. Main Body We outline implementation science approaches to embed EBI for SCD within the African context and highlight key implementation research programs for SCD management. Building implementation research capacity will meet the major need of developing effective life-long and accessible locally-tailored interventions for patients with SCD in Africa. Conclusion This commentary communicates the importance of the application of implementation science methodology to scale-up evidence-based interventions for the management of SCD in order to reduce pain, prevent other morbidities and premature death experienced by people with SCD in Africa, and improve their overall quality of life. |
topic |
Global health Implementation science research Sickle cell disease Africa Scale-up |
url |
https://doi.org/10.1186/s12992-021-00671-x |
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