Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations

Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations

The FLT3 Internal Tandem Duplication (FLT3ITD) mutation is common in adult acute myeloid leukemia (AML) but rare in early childhood AML. It is not clear why this difference occurs. Here we show that Flt3ITD and cooperating Flt3ITD/Runx1 mutations cause hematopoietic stem cell depletion and myeloid p...

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Bibliographic Details
Main Authors: Shaina N Porter, Andrew S Cluster, Wei Yang, Kelsey A Busken, Riddhi M Patel, Jiyeon Ryoo, Jeffrey A Magee
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-11-01
Series:eLife
Subjects:
hematopoietic stem cell
Flt3 Internal tandem duplication
acute myeloid leukemia
Online Access:https://elifesciences.org/articles/18882

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