Hypothalamic pituitary thyroid axis and exposure to interpersonal violence in childhood among women with borderline personality disorder
Background: A relationship between exposure to sexual violence and thyroid hormone alterations has been observed among women with posttraumatic stress disorder (PTSD). Women with borderline personality disorder (BPD) report a high estimate of childhood trauma. Objective: The aim of the present study...
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doaj-6f6b0235d97a4d0fb95a58a108d779cc2020-11-25T01:50:22ZengTaylor & Francis GroupEuropean Journal of Psychotraumatology2000-80662014-05-01501910.3402/ejpt.v5.2391123911Hypothalamic pituitary thyroid axis and exposure to interpersonal violence in childhood among women with borderline personality disorderCave Sinai0Tatja Hirvikoski1Anna-Lena Nordström2Peter Nordström3Åsa Nilsonne4Alexander Wilczek5Marie Åsberg6Jussi Jokinen7 Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden Department of Children's and Women's Health, Center for Neurodevelopmental Disorders at Karolinska Institutet (KIND), Stockholm, Sweden Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Karolinska University Hospital, Solna, SwedenBackground: A relationship between exposure to sexual violence and thyroid hormone alterations has been observed among women with posttraumatic stress disorder (PTSD). Women with borderline personality disorder (BPD) report a high estimate of childhood trauma. Objective: The aim of the present study was to assess relationships between thyroid hormone measures and exposure to violence in childhood in women with BPD. Method: A total of 92 clinically euthyroid women with BPD (53% with comorbid PTSD) diagnosis and at least two prior suicide attempts were assessed with the Karolinska Interpersonal Violence Scales (KIVS). The KIVS contains four subscales with concrete examples of exposure to violence and expressed violent behavior in childhood (aged 6–14 years) and during adult life (15 years or older). Baseline thyroid function was evaluated by measuring plasma free and bound triiodothyronine (FT3 and T3), thyroxine (FT4 and T4), and thyroid-stimulating hormone (TSH) with immunoassays. The FT3/FT4 ratio was used to estimate peripheral deiodination. Plasma cortisol was also assessed. Results: Sixty-seven percent of patients reported medium high or high level of exposure to interpersonal violence as a child. The FT3/FT4 ratio showed a significant negative correlation with exposure to violence as a child. Patients with PTSD had significantly higher plasma cortisol levels. An ad hoc analysis revealed that the correlation between KIVS exposure to interpersonal violence as a child and FT3/FT4 ratio was significant only in patients with comorbid PTSD. Altered thyroid activity, especially FT3/FT4, levels was associated with exposure to violence in childhood in women with BPD. Conclusion: Severe childhood trauma-related stress may promote lasting altered thyroid levels and/or contribute to the development of psychopathology associated with BPD traits or PTSD.http://www.ejpt.net/index.php/ejpt/article/download/23911/pdf_1HPT axisthyroid hormonesborderline personality disorderinterpersonal violencechildhood adverse eventschildhood maltreatmenttraumastress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cave Sinai Tatja Hirvikoski Anna-Lena Nordström Peter Nordström Åsa Nilsonne Alexander Wilczek Marie Åsberg Jussi Jokinen |
spellingShingle |
Cave Sinai Tatja Hirvikoski Anna-Lena Nordström Peter Nordström Åsa Nilsonne Alexander Wilczek Marie Åsberg Jussi Jokinen Hypothalamic pituitary thyroid axis and exposure to interpersonal violence in childhood among women with borderline personality disorder European Journal of Psychotraumatology HPT axis thyroid hormones borderline personality disorder interpersonal violence childhood adverse events childhood maltreatment trauma stress |
author_facet |
Cave Sinai Tatja Hirvikoski Anna-Lena Nordström Peter Nordström Åsa Nilsonne Alexander Wilczek Marie Åsberg Jussi Jokinen |
author_sort |
Cave Sinai |
title |
Hypothalamic pituitary thyroid axis and exposure to interpersonal violence in childhood among women with borderline personality disorder |
title_short |
Hypothalamic pituitary thyroid axis and exposure to interpersonal violence in childhood among women with borderline personality disorder |
title_full |
Hypothalamic pituitary thyroid axis and exposure to interpersonal violence in childhood among women with borderline personality disorder |
title_fullStr |
Hypothalamic pituitary thyroid axis and exposure to interpersonal violence in childhood among women with borderline personality disorder |
title_full_unstemmed |
Hypothalamic pituitary thyroid axis and exposure to interpersonal violence in childhood among women with borderline personality disorder |
title_sort |
hypothalamic pituitary thyroid axis and exposure to interpersonal violence in childhood among women with borderline personality disorder |
publisher |
Taylor & Francis Group |
series |
European Journal of Psychotraumatology |
issn |
2000-8066 |
publishDate |
2014-05-01 |
description |
Background: A relationship between exposure to sexual violence and thyroid hormone alterations has been observed among women with posttraumatic stress disorder (PTSD). Women with borderline personality disorder (BPD) report a high estimate of childhood trauma. Objective: The aim of the present study was to assess relationships between thyroid hormone measures and exposure to violence in childhood in women with BPD. Method: A total of 92 clinically euthyroid women with BPD (53% with comorbid PTSD) diagnosis and at least two prior suicide attempts were assessed with the Karolinska Interpersonal Violence Scales (KIVS). The KIVS contains four subscales with concrete examples of exposure to violence and expressed violent behavior in childhood (aged 6–14 years) and during adult life (15 years or older). Baseline thyroid function was evaluated by measuring plasma free and bound triiodothyronine (FT3 and T3), thyroxine (FT4 and T4), and thyroid-stimulating hormone (TSH) with immunoassays. The FT3/FT4 ratio was used to estimate peripheral deiodination. Plasma cortisol was also assessed. Results: Sixty-seven percent of patients reported medium high or high level of exposure to interpersonal violence as a child. The FT3/FT4 ratio showed a significant negative correlation with exposure to violence as a child. Patients with PTSD had significantly higher plasma cortisol levels. An ad hoc analysis revealed that the correlation between KIVS exposure to interpersonal violence as a child and FT3/FT4 ratio was significant only in patients with comorbid PTSD. Altered thyroid activity, especially FT3/FT4, levels was associated with exposure to violence in childhood in women with BPD. Conclusion: Severe childhood trauma-related stress may promote lasting altered thyroid levels and/or contribute to the development of psychopathology associated with BPD traits or PTSD. |
topic |
HPT axis thyroid hormones borderline personality disorder interpersonal violence childhood adverse events childhood maltreatment trauma stress |
url |
http://www.ejpt.net/index.php/ejpt/article/download/23911/pdf_1 |
work_keys_str_mv |
AT cavesinai hypothalamicpituitarythyroidaxisandexposuretointerpersonalviolenceinchildhoodamongwomenwithborderlinepersonalitydisorder AT tatjahirvikoski hypothalamicpituitarythyroidaxisandexposuretointerpersonalviolenceinchildhoodamongwomenwithborderlinepersonalitydisorder AT annalenanordstrom hypothalamicpituitarythyroidaxisandexposuretointerpersonalviolenceinchildhoodamongwomenwithborderlinepersonalitydisorder AT peternordstrom hypothalamicpituitarythyroidaxisandexposuretointerpersonalviolenceinchildhoodamongwomenwithborderlinepersonalitydisorder AT asanilsonne hypothalamicpituitarythyroidaxisandexposuretointerpersonalviolenceinchildhoodamongwomenwithborderlinepersonalitydisorder AT alexanderwilczek hypothalamicpituitarythyroidaxisandexposuretointerpersonalviolenceinchildhoodamongwomenwithborderlinepersonalitydisorder AT marieasberg hypothalamicpituitarythyroidaxisandexposuretointerpersonalviolenceinchildhoodamongwomenwithborderlinepersonalitydisorder AT jussijokinen hypothalamicpituitarythyroidaxisandexposuretointerpersonalviolenceinchildhoodamongwomenwithborderlinepersonalitydisorder |
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