Effectiveness of intravitreal chemotherapy-assisted endoresection in monocular patients with group D retinoblastoma
Abstract Background This study aimed to determine the efficacy and complications of intravitreal chemotherapy-assisted endoresection for refractory International Classification of Retinoblastoma (ICRB) group D retinoblastoma in monocular patients. Methods In this retrospective case series, intravitr...
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doaj-6f7b402492244a4abfb9478f53ceec942020-11-25T03:54:23ZengBMCBMC Cancer1471-24072020-08-012011710.1186/s12885-020-07314-1Effectiveness of intravitreal chemotherapy-assisted endoresection in monocular patients with group D retinoblastomaXiling Yu0Xueke Li1Yue Xing2Siduo Lu3Silvia Tanumiharjo4Jin Ma5Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen UniversityZhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen UniversityZhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen UniversityZhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen UniversityZhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen UniversityZhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen UniversityAbstract Background This study aimed to determine the efficacy and complications of intravitreal chemotherapy-assisted endoresection for refractory International Classification of Retinoblastoma (ICRB) group D retinoblastoma in monocular patients. Methods In this retrospective case series, intravitreal chemotherapy-assisted endoresection by pars plana vitrectomy was performed in 11 eyes with refractory ICRB group D retinoblastoma unresponsive to standard therapies in monocular patients. Results Across a mean follow-up period of 42.7 months, globe salvage was attained in all 11 eyes (100%). There were no cases of extra-ocular tumour seeding or remote metastasis. In 9 eyes (81.8%), tumour control was achieved with one pars plana vitrectomy; in 2 cases (18.2%), repeated treatment, such as laser therapy, intravitreal chemotherapy or a second pars plana vitrectomy, was needed. Retinal reattachment was achieved in all 4 eyes (100%) with previous retinal detachment. Four eyes (36.4%) required subsequent cataract surgery due to secondary cataract. Ten eyes (90.9%) had improvement in best-corrected visual acuity at the last follow-up. Conclusion Intravitreal chemotherapy-assisted endoresection appears to be a safe and effective globe-salvaging method for refractory group D retinoblastoma. It is a promising alternative to enucleation and a supplementary therapeutic strategy for those unresponsive to standard therapies, especially for the monocular retinoblastoma patients.http://link.springer.com/article/10.1186/s12885-020-07314-1Refractory retinoblastomaIntravitreal chemotherapyEndoresectionPars plana vitrectomy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiling Yu Xueke Li Yue Xing Siduo Lu Silvia Tanumiharjo Jin Ma |
spellingShingle |
Xiling Yu Xueke Li Yue Xing Siduo Lu Silvia Tanumiharjo Jin Ma Effectiveness of intravitreal chemotherapy-assisted endoresection in monocular patients with group D retinoblastoma BMC Cancer Refractory retinoblastoma Intravitreal chemotherapy Endoresection Pars plana vitrectomy |
author_facet |
Xiling Yu Xueke Li Yue Xing Siduo Lu Silvia Tanumiharjo Jin Ma |
author_sort |
Xiling Yu |
title |
Effectiveness of intravitreal chemotherapy-assisted endoresection in monocular patients with group D retinoblastoma |
title_short |
Effectiveness of intravitreal chemotherapy-assisted endoresection in monocular patients with group D retinoblastoma |
title_full |
Effectiveness of intravitreal chemotherapy-assisted endoresection in monocular patients with group D retinoblastoma |
title_fullStr |
Effectiveness of intravitreal chemotherapy-assisted endoresection in monocular patients with group D retinoblastoma |
title_full_unstemmed |
Effectiveness of intravitreal chemotherapy-assisted endoresection in monocular patients with group D retinoblastoma |
title_sort |
effectiveness of intravitreal chemotherapy-assisted endoresection in monocular patients with group d retinoblastoma |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2020-08-01 |
description |
Abstract Background This study aimed to determine the efficacy and complications of intravitreal chemotherapy-assisted endoresection for refractory International Classification of Retinoblastoma (ICRB) group D retinoblastoma in monocular patients. Methods In this retrospective case series, intravitreal chemotherapy-assisted endoresection by pars plana vitrectomy was performed in 11 eyes with refractory ICRB group D retinoblastoma unresponsive to standard therapies in monocular patients. Results Across a mean follow-up period of 42.7 months, globe salvage was attained in all 11 eyes (100%). There were no cases of extra-ocular tumour seeding or remote metastasis. In 9 eyes (81.8%), tumour control was achieved with one pars plana vitrectomy; in 2 cases (18.2%), repeated treatment, such as laser therapy, intravitreal chemotherapy or a second pars plana vitrectomy, was needed. Retinal reattachment was achieved in all 4 eyes (100%) with previous retinal detachment. Four eyes (36.4%) required subsequent cataract surgery due to secondary cataract. Ten eyes (90.9%) had improvement in best-corrected visual acuity at the last follow-up. Conclusion Intravitreal chemotherapy-assisted endoresection appears to be a safe and effective globe-salvaging method for refractory group D retinoblastoma. It is a promising alternative to enucleation and a supplementary therapeutic strategy for those unresponsive to standard therapies, especially for the monocular retinoblastoma patients. |
topic |
Refractory retinoblastoma Intravitreal chemotherapy Endoresection Pars plana vitrectomy |
url |
http://link.springer.com/article/10.1186/s12885-020-07314-1 |
work_keys_str_mv |
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