Effect of Hydrocortisone on Angiotensinogen (<i>AGT</i>) Mutation–Causing Autosomal Recessive Renal Tubular Dysgenesis

Effect of Hydrocortisone on Angiotensinogen (<i>AGT</i>) Mutation–Causing Autosomal Recessive Renal Tubular Dysgenesis

We has identified a founder homozygous E3_E4 del: 2870 bp deletion + 9 bp insertion in <i>AGT</i> gene encoding angiotensinogen responsible for autosomal recessive renal tubular dysgenesis (ARRTD) with nearly-fatal outcome. High-dose hydrocortisone therapy successfully rescued one patien...

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Bibliographic Details
Main Authors: Min-Hua Tseng, Shih-Ming Huang, Martin Konrad, Jing-Long Huang, Steven W. Shaw, Ya-Chung Tian, Ho-Yen Chueh, Wen-Lang Fan, Tai-Wei Wu, Jhao-Jhuang Ding, Ming-Chou Chiang, Shih-Hua Lin
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
renal tubular dysgenesis
angiotensinogen
rescue therapy
founder effect
Online Access:https://www.mdpi.com/2073-4409/10/4/782

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