Speckle-type POZ protein functions as a tumor suppressor in non-small cell lung cancer due to DNA methylation

Speckle-type POZ protein functions as a tumor suppressor in non-small cell lung cancer due to DNA methylation

Abstract Background Tumor suppressor epigenetic silencing plays an important role in non-small cell lung cancer (NSCLC) development and progression. Previously, the expression of speckle-type POZ protein (SPOP) has been found to be significantly inhibited in NSCLC. Our research aimed to investigate...

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Bibliographic Details
Main Authors: Sumei Yao, Xinming Chen, Jinliang Chen, Yangbo Guan, Yifei Liu, Jianrong Chen, Xuedong Lv
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Cancer Cell International
Subjects:
DNA methylation
NSCLC
C/EBPα
SPOP
Transcriptional regulation
Online Access:http://link.springer.com/article/10.1186/s12935-018-0711-z

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