Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information
Matrix metalloproteinase enzymes are widely known to contribute to the breakdown of tissues. Here, the authors utilise a biomaterial substrate functionalised with a laminin fragment to modulate the expression of these enzymes, subsequently controlling the integrity of tissue.
Bibliographic Details
Main Authors: |
Christine-Maria Horejs,
Jean-Philippe St-Pierre,
Juha R. M. Ojala,
Joseph A. M. Steele,
Patricia Barros da Silva,
Angela Rynne-Vidal,
Stephanie A. Maynard,
Catherine S. Hansel,
Clara Rodríguez-Fernández,
Manuel M. Mazo,
Amanda Y. F. You,
Alex J. Wang,
Thomas von Erlach,
Karl Tryggvason,
Manuel López-Cabrera,
Molly M. Stevens |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2017-06-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/ncomms15509
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