Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat
Reactive oxygen species (ROS) are essential for cellular signaling and response to stress. The level of ROS and the type of ROS determine the ability of cells to undergo cell death. Furthermore, dysregulation of the antioxidant pathways is associated with many diseases. It has become apparent that c...
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Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2021/9912436 |
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doaj-6f9a0c18aec84861b4a9329e6fe4aae52021-08-23T01:32:31ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09942021-01-01202110.1155/2021/9912436Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a RheostatGloria E. Villalpando-Rodriguez0Spencer B. Gibson1Research Institute in Oncology and HematologyResearch Institute in Oncology and HematologyReactive oxygen species (ROS) are essential for cellular signaling and response to stress. The level of ROS and the type of ROS determine the ability of cells to undergo cell death. Furthermore, dysregulation of the antioxidant pathways is associated with many diseases. It has become apparent that cell death can occur through different mechanisms leading to the classifications of different types of cell death such as apoptosis, ferroptosis, and necroptosis. ROS play essential roles in all forms of cell death, but it is only now coming into focus that ROS control and determine the type of cell death that occurs in any given cell. Indeed, ROS may act as a rheostat allowing different cell death mechanisms to be engaged and crosstalk with different cell death types. In this review, we will describe the ROS regulatory pathways and how they control different types of cell death under normal and disease states. We will also propose how ROS could provide a mechanism of crosstalk between cell death mechanisms and act as a rheostat determining the type of cell death.http://dx.doi.org/10.1155/2021/9912436 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gloria E. Villalpando-Rodriguez Spencer B. Gibson |
spellingShingle |
Gloria E. Villalpando-Rodriguez Spencer B. Gibson Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat Oxidative Medicine and Cellular Longevity |
author_facet |
Gloria E. Villalpando-Rodriguez Spencer B. Gibson |
author_sort |
Gloria E. Villalpando-Rodriguez |
title |
Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat |
title_short |
Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat |
title_full |
Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat |
title_fullStr |
Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat |
title_full_unstemmed |
Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat |
title_sort |
reactive oxygen species (ros) regulates different types of cell death by acting as a rheostat |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0994 |
publishDate |
2021-01-01 |
description |
Reactive oxygen species (ROS) are essential for cellular signaling and response to stress. The level of ROS and the type of ROS determine the ability of cells to undergo cell death. Furthermore, dysregulation of the antioxidant pathways is associated with many diseases. It has become apparent that cell death can occur through different mechanisms leading to the classifications of different types of cell death such as apoptosis, ferroptosis, and necroptosis. ROS play essential roles in all forms of cell death, but it is only now coming into focus that ROS control and determine the type of cell death that occurs in any given cell. Indeed, ROS may act as a rheostat allowing different cell death mechanisms to be engaged and crosstalk with different cell death types. In this review, we will describe the ROS regulatory pathways and how they control different types of cell death under normal and disease states. We will also propose how ROS could provide a mechanism of crosstalk between cell death mechanisms and act as a rheostat determining the type of cell death. |
url |
http://dx.doi.org/10.1155/2021/9912436 |
work_keys_str_mv |
AT gloriaevillalpandorodriguez reactiveoxygenspeciesrosregulatesdifferenttypesofcelldeathbyactingasarheostat AT spencerbgibson reactiveoxygenspeciesrosregulatesdifferenttypesofcelldeathbyactingasarheostat |
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1721198974995529728 |