Gut Microbiota Linked to Sexual Preference and HIV Infection
The precise effects of HIV-1 on the gut microbiome are unclear. Initial cross-sectional studies provided contradictory associations between microbial richness and HIV serostatus and suggested shifts from Bacteroides to Prevotella predominance following HIV-1 infection, which have not been found in a...
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Elsevier
2016-03-01
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Series: | EBioMedicine |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396416300287 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marc Noguera-Julian Muntsa Rocafort Yolanda Guillén Javier Rivera Maria Casadellà Piotr Nowak Falk Hildebrand Georg Zeller Mariona Parera Rocío Bellido Cristina Rodríguez Jorge Carrillo Beatriz Mothe Josep Coll Isabel Bravo Carla Estany Cristina Herrero Jorge Saz Guillem Sirera Ariadna Torrela Jordi Navarro Manel Crespo Christian Brander Eugènia Negredo Julià Blanco Francisco Guarner Maria Luz Calle Peer Bork Anders Sönnerborg Bonaventura Clotet Roger Paredes |
spellingShingle |
Marc Noguera-Julian Muntsa Rocafort Yolanda Guillén Javier Rivera Maria Casadellà Piotr Nowak Falk Hildebrand Georg Zeller Mariona Parera Rocío Bellido Cristina Rodríguez Jorge Carrillo Beatriz Mothe Josep Coll Isabel Bravo Carla Estany Cristina Herrero Jorge Saz Guillem Sirera Ariadna Torrela Jordi Navarro Manel Crespo Christian Brander Eugènia Negredo Julià Blanco Francisco Guarner Maria Luz Calle Peer Bork Anders Sönnerborg Bonaventura Clotet Roger Paredes Gut Microbiota Linked to Sexual Preference and HIV Infection EBioMedicine HIV-1 Microbiome Microbiota 16S rDNA Prevotella Bacteroides |
author_facet |
Marc Noguera-Julian Muntsa Rocafort Yolanda Guillén Javier Rivera Maria Casadellà Piotr Nowak Falk Hildebrand Georg Zeller Mariona Parera Rocío Bellido Cristina Rodríguez Jorge Carrillo Beatriz Mothe Josep Coll Isabel Bravo Carla Estany Cristina Herrero Jorge Saz Guillem Sirera Ariadna Torrela Jordi Navarro Manel Crespo Christian Brander Eugènia Negredo Julià Blanco Francisco Guarner Maria Luz Calle Peer Bork Anders Sönnerborg Bonaventura Clotet Roger Paredes |
author_sort |
Marc Noguera-Julian |
title |
Gut Microbiota Linked to Sexual Preference and HIV Infection |
title_short |
Gut Microbiota Linked to Sexual Preference and HIV Infection |
title_full |
Gut Microbiota Linked to Sexual Preference and HIV Infection |
title_fullStr |
Gut Microbiota Linked to Sexual Preference and HIV Infection |
title_full_unstemmed |
Gut Microbiota Linked to Sexual Preference and HIV Infection |
title_sort |
gut microbiota linked to sexual preference and hiv infection |
publisher |
Elsevier |
series |
EBioMedicine |
issn |
2352-3964 |
publishDate |
2016-03-01 |
description |
The precise effects of HIV-1 on the gut microbiome are unclear. Initial cross-sectional studies provided contradictory associations between microbial richness and HIV serostatus and suggested shifts from Bacteroides to Prevotella predominance following HIV-1 infection, which have not been found in animal models or in studies matched for HIV-1 transmission groups. In two independent cohorts of HIV-1-infected subjects and HIV-1-negative controls in Barcelona (n = 156) and Stockholm (n = 84), men who have sex with men (MSM) predominantly belonged to the Prevotella-rich enterotype whereas most non-MSM subjects were enriched in Bacteroides, independently of HIV-1 status, and with only a limited contribution of diet effects. Moreover, MSM had a significantly richer and more diverse fecal microbiota than non-MSM individuals. After stratifying for sexual orientation, there was no solid evidence of an HIV-specific dysbiosis. However, HIV-1 infection remained consistently associated with reduced bacterial richness, the lowest bacterial richness being observed in subjects with a virological-immune discordant response to antiretroviral therapy. Our findings indicate that HIV gut microbiome studies must control for HIV risk factors and suggest interventions on gut bacterial richness as possible novel avenues to improve HIV-1-associated immune dysfunction. |
topic |
HIV-1 Microbiome Microbiota 16S rDNA Prevotella Bacteroides |
url |
http://www.sciencedirect.com/science/article/pii/S2352396416300287 |
work_keys_str_mv |
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doaj-6faa3211ce75425d932a4c38e15aad482020-11-25T01:38:41ZengElsevierEBioMedicine2352-39642016-03-015C13514610.1016/j.ebiom.2016.01.032Gut Microbiota Linked to Sexual Preference and HIV InfectionMarc Noguera-Julian0Muntsa Rocafort1Yolanda Guillén2Javier Rivera3Maria Casadellà4Piotr Nowak5Falk Hildebrand6Georg Zeller7Mariona Parera8Rocío Bellido9Cristina Rodríguez10Jorge Carrillo11Beatriz Mothe12Josep Coll13Isabel Bravo14Carla Estany15Cristina Herrero16Jorge Saz17Guillem Sirera18Ariadna Torrela19Jordi Navarro20Manel Crespo21Christian Brander22Eugènia Negredo23Julià Blanco24Francisco Guarner25Maria Luz Calle26Peer Bork27Anders Sönnerborg28Bonaventura Clotet29Roger Paredes30IrsiCaixa AIDS Research Institute, Ctra de Canyet s/n, 08916 Badalona, Catalonia, SpainIrsiCaixa AIDS Research Institute, Ctra de Canyet s/n, 08916 Badalona, Catalonia, SpainIrsiCaixa AIDS Research Institute, Ctra de Canyet s/n, 08916 Badalona, Catalonia, SpainIrsiCaixa AIDS Research Institute, Ctra de Canyet s/n, 08916 Badalona, Catalonia, SpainIrsiCaixa AIDS Research Institute, Ctra de Canyet s/n, 08916 Badalona, Catalonia, SpainDepartment of Medicine, Unit of Infectious Diseases, Karolinska University Hospital, Karolinska Institutet, Huddinge 141, 86, Stockholm, SwedenStructural and Computational Biology, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, GermanyStructural and Computational Biology, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, GermanyIrsiCaixa AIDS Research Institute, Ctra de Canyet s/n, 08916 Badalona, Catalonia, SpainIrsiCaixa AIDS Research Institute, Ctra de Canyet s/n, 08916 Badalona, Catalonia, SpainIrsiCaixa AIDS Research Institute, Ctra de Canyet s/n, 08916 Badalona, Catalonia, SpainIrsiCaixa AIDS Research Institute, Ctra de Canyet s/n, 08916 Badalona, Catalonia, SpainIrsiCaixa AIDS Research Institute, Ctra de Canyet s/n, 08916 Badalona, Catalonia, SpainIrsiCaixa AIDS Research Institute, Ctra de Canyet s/n, 08916 Badalona, Catalonia, SpainHIV Unit & Lluita Contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Ctra de Canyet s/n, 08916 Badalona, Catalonia, SpainHIV Unit & Lluita Contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Ctra de Canyet s/n, 08916 Badalona, Catalonia, SpainHIV Unit & Lluita Contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Ctra de Canyet s/n, 08916 Badalona, Catalonia, SpainBCN Checkpoint, Carrer del Comte Borrell, 164, 08015 Barcelona, Catalonia, SpainHIV Unit & Lluita Contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Ctra de Canyet s/n, 08916 Badalona, Catalonia, SpainInfectious Diseases Unit, Hospital Universitari Vall d'Hebrón, Passeig de la Vall d'Hebrón, 119–129, 08035 Barcelona, Catalonia, SpainInfectious Diseases Unit, Hospital Universitari Vall d'Hebrón, Passeig de la Vall d'Hebrón, 119–129, 08035 Barcelona, Catalonia, SpainInfectious Diseases Unit, Hospital Universitari Vall d'Hebrón, Passeig de la Vall d'Hebrón, 119–129, 08035 Barcelona, Catalonia, SpainIrsiCaixa AIDS Research Institute, Ctra de Canyet s/n, 08916 Badalona, Catalonia, SpainUniversitat de Vic-Universitat Central de Catalunya, C. Sagrada Família 7, 08500 Vic, Catalonia, SpainIrsiCaixa AIDS Research Institute, Ctra de Canyet s/n, 08916 Badalona, Catalonia, SpainDigestive Diseases Department, Vall d'Hebrón Institute of Research, Hospital Universitari Vall d'Hebrón, Passeig de la Vall d'Hebrón, 119–129, 08035 Barcelona, Catalonia, SpainUniversitat de Vic-Universitat Central de Catalunya, C. Sagrada Família 7, 08500 Vic, Catalonia, SpainStructural and Computational Biology, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, GermanyDepartment of Medicine, Unit of Infectious Diseases, Karolinska University Hospital, Karolinska Institutet, Huddinge 141, 86, Stockholm, SwedenIrsiCaixa AIDS Research Institute, Ctra de Canyet s/n, 08916 Badalona, Catalonia, SpainIrsiCaixa AIDS Research Institute, Ctra de Canyet s/n, 08916 Badalona, Catalonia, SpainThe precise effects of HIV-1 on the gut microbiome are unclear. Initial cross-sectional studies provided contradictory associations between microbial richness and HIV serostatus and suggested shifts from Bacteroides to Prevotella predominance following HIV-1 infection, which have not been found in animal models or in studies matched for HIV-1 transmission groups. In two independent cohorts of HIV-1-infected subjects and HIV-1-negative controls in Barcelona (n = 156) and Stockholm (n = 84), men who have sex with men (MSM) predominantly belonged to the Prevotella-rich enterotype whereas most non-MSM subjects were enriched in Bacteroides, independently of HIV-1 status, and with only a limited contribution of diet effects. Moreover, MSM had a significantly richer and more diverse fecal microbiota than non-MSM individuals. After stratifying for sexual orientation, there was no solid evidence of an HIV-specific dysbiosis. However, HIV-1 infection remained consistently associated with reduced bacterial richness, the lowest bacterial richness being observed in subjects with a virological-immune discordant response to antiretroviral therapy. Our findings indicate that HIV gut microbiome studies must control for HIV risk factors and suggest interventions on gut bacterial richness as possible novel avenues to improve HIV-1-associated immune dysfunction.http://www.sciencedirect.com/science/article/pii/S2352396416300287HIV-1MicrobiomeMicrobiota16S rDNAPrevotellaBacteroides |