A viral guide RNA delivery system for CRISPR-based transcriptional activation and heritable targeted DNA demethylation in Arabidopsis thaliana.

A viral guide RNA delivery system for CRISPR-based transcriptional activation and heritable targeted DNA demethylation in Arabidopsis thaliana.

Plant RNA viruses are used as delivery vectors for their high level of accumulation and efficient spread during virus multiplication and movement. Utilizing this concept, several viral-based guide RNA delivery platforms for CRISPR-Cas9 genome editing have been developed. The CRISPR-Cas9 system has a...

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Bibliographic Details
Main Authors: Basudev Ghoshal, Brandon Vong, Colette L Picard, Suhua Feng, Janet M Tam, Steven E Jacobsen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-12-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008983

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