Control of diabetic hyperglycaemia and insulin resistance through TSC22D4

TSC22D4 regulates hepatic lipoprotein production, but has so far mainly been studied in the context of cancer cachexia. Here, the authors show TSC22D4 inhibition improves insulin sensitivity in several mouse models of diabetes, which they attribute at least in part to the induction of secreted LCN13...

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Main Authors:	Bilgen Ekim Üstünel, Kilian Friedrich, Adriano Maida, Xiaoyue Wang, Anja Krones-Herzig, Oksana Seibert, Anke Sommerfeld, Allan Jones, Tjeerd P. Sijmonsma, Carsten Sticht, Norbert Gretz, Thomas Fleming, Peter P. Nawroth, Wolfgang Stremmel, Adam J. Rose, Mauricio Berriel-Diaz, Matthias Blüher, Stephan Herzig
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms13267

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spelling	doaj-6fbad84b0b124d8487619a25d73053a22021-05-11T10:48:16ZengNature Publishing GroupNature Communications2041-17232016-11-017111110.1038/ncomms13267Control of diabetic hyperglycaemia and insulin resistance through TSC22D4Bilgen Ekim Üstünel0Kilian Friedrich1Adriano Maida2Xiaoyue Wang3Anja Krones-Herzig4Oksana Seibert5Anke Sommerfeld6Allan Jones7Tjeerd P. Sijmonsma8Carsten Sticht9Norbert Gretz10Thomas Fleming11Peter P. Nawroth12Wolfgang Stremmel13Adam J. Rose14Mauricio Berriel-Diaz15Matthias Blüher16Stephan Herzig17Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramCenter for Clinical Research, Medical Faculty MannheimCenter for Clinical Research, Medical Faculty MannheimDepartment of Medicine I and Clinical Chemistry, Heidelberg UniversityDepartment of Medicine I and Clinical Chemistry, Heidelberg UniversityDepartment of Internal Medicine IV, Heidelberg University HospitalInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramDepartment of Medicine, University of LeipzigInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramTSC22D4 regulates hepatic lipoprotein production, but has so far mainly been studied in the context of cancer cachexia. Here, the authors show TSC22D4 inhibition improves insulin sensitivity in several mouse models of diabetes, which they attribute at least in part to the induction of secreted LCN13.https://doi.org/10.1038/ncomms13267
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Bilgen Ekim Üstünel Kilian Friedrich Adriano Maida Xiaoyue Wang Anja Krones-Herzig Oksana Seibert Anke Sommerfeld Allan Jones Tjeerd P. Sijmonsma Carsten Sticht Norbert Gretz Thomas Fleming Peter P. Nawroth Wolfgang Stremmel Adam J. Rose Mauricio Berriel-Diaz Matthias Blüher Stephan Herzig
spellingShingle	Bilgen Ekim Üstünel Kilian Friedrich Adriano Maida Xiaoyue Wang Anja Krones-Herzig Oksana Seibert Anke Sommerfeld Allan Jones Tjeerd P. Sijmonsma Carsten Sticht Norbert Gretz Thomas Fleming Peter P. Nawroth Wolfgang Stremmel Adam J. Rose Mauricio Berriel-Diaz Matthias Blüher Stephan Herzig Control of diabetic hyperglycaemia and insulin resistance through TSC22D4 Nature Communications
author_facet	Bilgen Ekim Üstünel Kilian Friedrich Adriano Maida Xiaoyue Wang Anja Krones-Herzig Oksana Seibert Anke Sommerfeld Allan Jones Tjeerd P. Sijmonsma Carsten Sticht Norbert Gretz Thomas Fleming Peter P. Nawroth Wolfgang Stremmel Adam J. Rose Mauricio Berriel-Diaz Matthias Blüher Stephan Herzig
author_sort	Bilgen Ekim Üstünel
title	Control of diabetic hyperglycaemia and insulin resistance through TSC22D4
title_short	Control of diabetic hyperglycaemia and insulin resistance through TSC22D4
title_full	Control of diabetic hyperglycaemia and insulin resistance through TSC22D4
title_fullStr	Control of diabetic hyperglycaemia and insulin resistance through TSC22D4
title_full_unstemmed	Control of diabetic hyperglycaemia and insulin resistance through TSC22D4
title_sort	control of diabetic hyperglycaemia and insulin resistance through tsc22d4
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-11-01
description	TSC22D4 regulates hepatic lipoprotein production, but has so far mainly been studied in the context of cancer cachexia. Here, the authors show TSC22D4 inhibition improves insulin sensitivity in several mouse models of diabetes, which they attribute at least in part to the induction of secreted LCN13.
url	https://doi.org/10.1038/ncomms13267
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Control of diabetic hyperglycaemia and insulin resistance through TSC22D4

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