Fel d1 Blocking Antibodies: A Novel Method to Reduce IgE-Mediated Allergy to Cats
Fel d1 is an important allergen produced by cats that causes IgE reactions in up to 95% of cat-allergic adults. Immunotherapy to reduce human allergy to cats has demonstrated that people have the capacity to produce allergen-specific neutralizing antibodies that block IgE-mediated allergic responses...
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Hindawi Limited
2021-01-01
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Series: | Journal of Immunology Research |
Online Access: | http://dx.doi.org/10.1155/2021/5545173 |
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doaj-6fbec05af26941b998c42a353bf6d31e2021-07-05T00:01:51ZengHindawi LimitedJournal of Immunology Research2314-71562021-01-01202110.1155/2021/5545173Fel d1 Blocking Antibodies: A Novel Method to Reduce IgE-Mediated Allergy to CatsEbenezer Satyaraj0Peichuan Sun1Scott Sherrill2Nestlé Purina ResearchNestlé Purina ResearchNestlé Purina ResearchFel d1 is an important allergen produced by cats that causes IgE reactions in up to 95% of cat-allergic adults. Immunotherapy to reduce human allergy to cats has demonstrated that people have the capacity to produce allergen-specific neutralizing antibodies that block IgE-mediated allergic responses. We wished to determine if “blocking” antibodies could be used to reduce the IgE binding ability of cat allergens prior to their exposure to humans. Here, we describe the characterization of Fel d1-specific antibodies. We demonstrated the efficacy of a rabbit polyclonal and an allergen-specific chicken IgY to bind to Fel d1 in cat saliva and block Fel d1-IgE binding and IgE-mediated basophil degranulation. Fel d1 blocking antibodies offer a new and exciting approach to the neutralization of cat allergens.http://dx.doi.org/10.1155/2021/5545173 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ebenezer Satyaraj Peichuan Sun Scott Sherrill |
spellingShingle |
Ebenezer Satyaraj Peichuan Sun Scott Sherrill Fel d1 Blocking Antibodies: A Novel Method to Reduce IgE-Mediated Allergy to Cats Journal of Immunology Research |
author_facet |
Ebenezer Satyaraj Peichuan Sun Scott Sherrill |
author_sort |
Ebenezer Satyaraj |
title |
Fel d1 Blocking Antibodies: A Novel Method to Reduce IgE-Mediated Allergy to Cats |
title_short |
Fel d1 Blocking Antibodies: A Novel Method to Reduce IgE-Mediated Allergy to Cats |
title_full |
Fel d1 Blocking Antibodies: A Novel Method to Reduce IgE-Mediated Allergy to Cats |
title_fullStr |
Fel d1 Blocking Antibodies: A Novel Method to Reduce IgE-Mediated Allergy to Cats |
title_full_unstemmed |
Fel d1 Blocking Antibodies: A Novel Method to Reduce IgE-Mediated Allergy to Cats |
title_sort |
fel d1 blocking antibodies: a novel method to reduce ige-mediated allergy to cats |
publisher |
Hindawi Limited |
series |
Journal of Immunology Research |
issn |
2314-7156 |
publishDate |
2021-01-01 |
description |
Fel d1 is an important allergen produced by cats that causes IgE reactions in up to 95% of cat-allergic adults. Immunotherapy to reduce human allergy to cats has demonstrated that people have the capacity to produce allergen-specific neutralizing antibodies that block IgE-mediated allergic responses. We wished to determine if “blocking” antibodies could be used to reduce the IgE binding ability of cat allergens prior to their exposure to humans. Here, we describe the characterization of Fel d1-specific antibodies. We demonstrated the efficacy of a rabbit polyclonal and an allergen-specific chicken IgY to bind to Fel d1 in cat saliva and block Fel d1-IgE binding and IgE-mediated basophil degranulation. Fel d1 blocking antibodies offer a new and exciting approach to the neutralization of cat allergens. |
url |
http://dx.doi.org/10.1155/2021/5545173 |
work_keys_str_mv |
AT ebenezersatyaraj feld1blockingantibodiesanovelmethodtoreduceigemediatedallergytocats AT peichuansun feld1blockingantibodiesanovelmethodtoreduceigemediatedallergytocats AT scottsherrill feld1blockingantibodiesanovelmethodtoreduceigemediatedallergytocats |
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1721319491353182208 |