Clarithromycin versus levofloxacin-based regimens for Helicobacter pylori eradication in the Kurdistan Region of Iraq: A randomized clinical trial
Helicobacter pylori infection is a predisposing factor for gastric cancer. This prospective, randomized clinical trial aimed to compare H. pylori eradication rates associated with a clarithromycin-based regimen and levofloxacin-based regimen. H. pylori infection was confirmed by a rapid urease test...
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2019-09-01
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doaj-6fc3af32105440e2a23a4ba29119c1d42021-05-02T22:00:27ZengMDPI AGGastroenterology Insights2036-74142036-74222019-09-0110110.4081/gi.2019.8256Clarithromycin versus levofloxacin-based regimens for Helicobacter pylori eradication in the Kurdistan Region of Iraq: A randomized clinical trialShinah A. Mohammed0Omer Q. B. Al-lela1Nawfal R. Hussein2Ramadhan S. Hajany3Laween S. Alduhoky4College of Pharmacy, University of Duhok, Duhok, Kurdistan RegionCollege of Pharmacy, University of Duhok, Duhok, Kurdistan Region; Department of Pharmacy, Al-Noor University CollegeCollege of Medicine, University of Zakho, Kurdistan RegionCollege of Medicine, University of Duhok, Duhok, Kurdistan RegionAzadi Teaching Hospital, Duhok, Kurdistan Region Helicobacter pylori infection is a predisposing factor for gastric cancer. This prospective, randomized clinical trial aimed to compare H. pylori eradication rates associated with a clarithromycin-based regimen and levofloxacin-based regimen. H. pylori infection was confirmed by a rapid urease test during endoscopy and its eradication by a urea breath test. In this study, 192 patients were recruited; 93 patients received a clarithromycin- based regimen and 99 a levofloxacin- based regimen. Sixty-four patients completed the clarithromycinbased regimen and 60 the levofloxacinbased regimen. The eradication success rate of the clarithromycin-based regimen was 52/64 (81.25%), while that of the levofloxacin- based regimen was 49/60 (81.6%) (P=0.9524; odds ratio [OR]=1.0280; confidence interval [CI]=0.4153-2.5447). Investigation of the risk factors associated with treatment failure showed that the overall efficacy of the regimens was influenced by body mass index (BMI), with a high failure rate observed in patients with a high BMI (P=0.0174; OR=1.1116; CI=1.0187- 1.2129). Age, sex, endoscopic diagnosis and smoking did not influence treatment outcomes. Further studies are needed to monitor H. pylori antibiotic resistance rates. https://www.pagepress.org/journals/index.php/gi/article/view/8256Helicobacter pyloriEradicationLevofloxacinClarithromycinDuhokIraq |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shinah A. Mohammed Omer Q. B. Al-lela Nawfal R. Hussein Ramadhan S. Hajany Laween S. Alduhoky |
spellingShingle |
Shinah A. Mohammed Omer Q. B. Al-lela Nawfal R. Hussein Ramadhan S. Hajany Laween S. Alduhoky Clarithromycin versus levofloxacin-based regimens for Helicobacter pylori eradication in the Kurdistan Region of Iraq: A randomized clinical trial Gastroenterology Insights Helicobacter pylori Eradication Levofloxacin Clarithromycin Duhok Iraq |
author_facet |
Shinah A. Mohammed Omer Q. B. Al-lela Nawfal R. Hussein Ramadhan S. Hajany Laween S. Alduhoky |
author_sort |
Shinah A. Mohammed |
title |
Clarithromycin versus levofloxacin-based regimens for Helicobacter pylori eradication in the Kurdistan Region of Iraq: A randomized clinical trial |
title_short |
Clarithromycin versus levofloxacin-based regimens for Helicobacter pylori eradication in the Kurdistan Region of Iraq: A randomized clinical trial |
title_full |
Clarithromycin versus levofloxacin-based regimens for Helicobacter pylori eradication in the Kurdistan Region of Iraq: A randomized clinical trial |
title_fullStr |
Clarithromycin versus levofloxacin-based regimens for Helicobacter pylori eradication in the Kurdistan Region of Iraq: A randomized clinical trial |
title_full_unstemmed |
Clarithromycin versus levofloxacin-based regimens for Helicobacter pylori eradication in the Kurdistan Region of Iraq: A randomized clinical trial |
title_sort |
clarithromycin versus levofloxacin-based regimens for helicobacter pylori eradication in the kurdistan region of iraq: a randomized clinical trial |
publisher |
MDPI AG |
series |
Gastroenterology Insights |
issn |
2036-7414 2036-7422 |
publishDate |
2019-09-01 |
description |
Helicobacter pylori infection is a predisposing factor for gastric cancer. This prospective, randomized clinical trial aimed to compare H. pylori eradication rates associated with a clarithromycin-based regimen and levofloxacin-based regimen. H. pylori infection was confirmed by a rapid urease test during endoscopy and its eradication by a urea breath test. In this study, 192 patients were recruited; 93 patients received a clarithromycin- based regimen and 99 a levofloxacin- based regimen. Sixty-four patients completed the clarithromycinbased regimen and 60 the levofloxacinbased regimen. The eradication success rate of the clarithromycin-based regimen was 52/64 (81.25%), while that of the levofloxacin- based regimen was 49/60 (81.6%) (P=0.9524; odds ratio [OR]=1.0280; confidence interval [CI]=0.4153-2.5447). Investigation of the risk factors associated with treatment failure showed that the overall efficacy of the regimens was influenced by body mass index (BMI), with a high failure rate observed in patients with a high BMI (P=0.0174; OR=1.1116; CI=1.0187- 1.2129). Age, sex, endoscopic diagnosis and smoking did not influence treatment outcomes. Further studies are needed to monitor H. pylori antibiotic resistance rates.
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topic |
Helicobacter pylori Eradication Levofloxacin Clarithromycin Duhok Iraq |
url |
https://www.pagepress.org/journals/index.php/gi/article/view/8256 |
work_keys_str_mv |
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