| Summary: | Yu Li,1– 3 Qing Xiao,1– 3 Jie Tang,2– 4 Lidan Xiong,2– 4 Li Li1– 4 1Department of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Cosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 3NMPA Key Laboratory for Human Evaluation and Big Data of Cosmetics, Chengdu, 610041, People’s Republic of China; 4Sichuan Engineering Technology Research Center of Cosmetic, Chengdu, 610041, People’s Republic of ChinaCorrespondence: Li LiDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of ChinaEmail lilihx_scu@scu.edu.cnLidan XiongCosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, No. 5, Gong Xing Road, Chengdu, Sichuan, 610041, People’s Republic of ChinaEmail beardan0505@163.comAbstract: Extracellular vesicles (EVs), as nanoscale membranous vesicles containing DNAs, RNAs, lipids and proteins, have emerged as promising diagnostic and therapeutic agents for skin diseases. Here, we summarize the basic physiology of the skin and the biological characteristic of EVs. Further, we describe the applications of EVs in the treatment of dermatological conditions such as skin infection, inflammatory skin diseases, skin repair and rejuvenation and skin cancer. In particular, plant-derived EVs and clinical trials are discussed. In addition, challenges and perspectives related to the preclinical and clinical applications of EVs are highlighted.Keywords: extracellular vesicles, skin diseases, plant, clinical trials
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