Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions
Yu Li,1– 3 Qing Xiao,1– 3 Jie Tang,2– 4 Lidan Xiong,2– 4 Li Li1– 4 1Department of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Cosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, Chengdu, 610041, People’s Re...
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doaj-6fd355b6bd07452e99141ce94942e4442021-10-02T19:15:16ZengDove Medical PressInternational Journal of Nanomedicine1178-20132021-09-01Volume 166183620268540Extracellular Vesicles: Emerging Therapeutics in Cutaneous LesionsLi YXiao QTang JXiong LLi LYu Li,1– 3 Qing Xiao,1– 3 Jie Tang,2– 4 Lidan Xiong,2– 4 Li Li1– 4 1Department of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Cosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 3NMPA Key Laboratory for Human Evaluation and Big Data of Cosmetics, Chengdu, 610041, People’s Republic of China; 4Sichuan Engineering Technology Research Center of Cosmetic, Chengdu, 610041, People’s Republic of ChinaCorrespondence: Li LiDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of ChinaEmail lilihx_scu@scu.edu.cnLidan XiongCosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, No. 5, Gong Xing Road, Chengdu, Sichuan, 610041, People’s Republic of ChinaEmail beardan0505@163.comAbstract: Extracellular vesicles (EVs), as nanoscale membranous vesicles containing DNAs, RNAs, lipids and proteins, have emerged as promising diagnostic and therapeutic agents for skin diseases. Here, we summarize the basic physiology of the skin and the biological characteristic of EVs. Further, we describe the applications of EVs in the treatment of dermatological conditions such as skin infection, inflammatory skin diseases, skin repair and rejuvenation and skin cancer. In particular, plant-derived EVs and clinical trials are discussed. In addition, challenges and perspectives related to the preclinical and clinical applications of EVs are highlighted.Keywords: extracellular vesicles, skin diseases, plant, clinical trialshttps://www.dovepress.com/extracellular-vesicles-emerging-therapeutics-in-cutaneous-lesions-peer-reviewed-fulltext-article-IJNextracellular vesiclesskin diseasesplantclinical trials |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li Y Xiao Q Tang J Xiong L Li L |
spellingShingle |
Li Y Xiao Q Tang J Xiong L Li L Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions International Journal of Nanomedicine extracellular vesicles skin diseases plant clinical trials |
author_facet |
Li Y Xiao Q Tang J Xiong L Li L |
author_sort |
Li Y |
title |
Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions |
title_short |
Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions |
title_full |
Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions |
title_fullStr |
Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions |
title_full_unstemmed |
Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions |
title_sort |
extracellular vesicles: emerging therapeutics in cutaneous lesions |
publisher |
Dove Medical Press |
series |
International Journal of Nanomedicine |
issn |
1178-2013 |
publishDate |
2021-09-01 |
description |
Yu Li,1– 3 Qing Xiao,1– 3 Jie Tang,2– 4 Lidan Xiong,2– 4 Li Li1– 4 1Department of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Cosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 3NMPA Key Laboratory for Human Evaluation and Big Data of Cosmetics, Chengdu, 610041, People’s Republic of China; 4Sichuan Engineering Technology Research Center of Cosmetic, Chengdu, 610041, People’s Republic of ChinaCorrespondence: Li LiDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of ChinaEmail lilihx_scu@scu.edu.cnLidan XiongCosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, No. 5, Gong Xing Road, Chengdu, Sichuan, 610041, People’s Republic of ChinaEmail beardan0505@163.comAbstract: Extracellular vesicles (EVs), as nanoscale membranous vesicles containing DNAs, RNAs, lipids and proteins, have emerged as promising diagnostic and therapeutic agents for skin diseases. Here, we summarize the basic physiology of the skin and the biological characteristic of EVs. Further, we describe the applications of EVs in the treatment of dermatological conditions such as skin infection, inflammatory skin diseases, skin repair and rejuvenation and skin cancer. In particular, plant-derived EVs and clinical trials are discussed. In addition, challenges and perspectives related to the preclinical and clinical applications of EVs are highlighted.Keywords: extracellular vesicles, skin diseases, plant, clinical trials |
topic |
extracellular vesicles skin diseases plant clinical trials |
url |
https://www.dovepress.com/extracellular-vesicles-emerging-therapeutics-in-cutaneous-lesions-peer-reviewed-fulltext-article-IJN |
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