Ultrasound texture analysis: Association with lymph node metastasis of papillary thyroid microcarcinoma.
This retrospective study aimed to evaluate whether ultrasound texture analysis is useful to predict lymph node metastasis in patients with papillary thyroid microcarcinoma (PTMC). This study was approved by the Institutional Review Board, and the need to obtain informed consent was waived. Between M...
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doaj-6fe216f2e31d43f380cc9446e29c3be92020-11-25T02:02:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01124e017610310.1371/journal.pone.0176103Ultrasound texture analysis: Association with lymph node metastasis of papillary thyroid microcarcinoma.Soo-Yeon KimEunjung LeeSe Jin NamEun-Kyung KimHee Jung MoonJung Hyun YoonKyung Hwa HanJin Young KwakThis retrospective study aimed to evaluate whether ultrasound texture analysis is useful to predict lymph node metastasis in patients with papillary thyroid microcarcinoma (PTMC). This study was approved by the Institutional Review Board, and the need to obtain informed consent was waived. Between May and July 2013, 361 patients (mean age, 43.8 ± 11.3 years; range, 16-72 years) who underwent staging ultrasound (US) and subsequent thyroidectomy for conventional PTMC ≤ 10 mm between May and July 2013 were included. Each PTMC was manually segmented and its histogram parameters (Mean, Standard deviation, Skewness, Kurtosis, and Entropy) were extracted with Matlab software. The mean values of histogram parameters and clinical and US features were compared according to lymph node metastasis using the independent t-test and Chi-square test. Multivariate logistic regression analysis was performed to identify the independent factors associated with lymph node metastasis. Tumors with lymph node metastasis (n = 117) had significantly higher entropy compared to those without lymph node metastasis (n = 244) (mean±standard deviation, 6.268±0.407 vs. 6.171±.0.405; P = .035). No additional histogram parameters showed differences in mean values according to lymph node metastasis. Entropy was not independently associated with lymph node metastasis on multivariate logistic regression analysis (Odds ratio, 0.977 [95% confidence interval (CI), 0.482-1.980]; P = .949). Younger age (Odds ratio, 0.962 [95% CI, 0.940-0.984]; P = .001) and lymph node metastasis on US (Odds ratio, 7.325 [95% CI, 3.573-15.020]; P < .001) were independently associated with lymph node metastasis. Texture analysis was not useful in predicting lymph node metastasis in patients with PTMC.http://europepmc.org/articles/PMC5395228?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Soo-Yeon Kim Eunjung Lee Se Jin Nam Eun-Kyung Kim Hee Jung Moon Jung Hyun Yoon Kyung Hwa Han Jin Young Kwak |
spellingShingle |
Soo-Yeon Kim Eunjung Lee Se Jin Nam Eun-Kyung Kim Hee Jung Moon Jung Hyun Yoon Kyung Hwa Han Jin Young Kwak Ultrasound texture analysis: Association with lymph node metastasis of papillary thyroid microcarcinoma. PLoS ONE |
author_facet |
Soo-Yeon Kim Eunjung Lee Se Jin Nam Eun-Kyung Kim Hee Jung Moon Jung Hyun Yoon Kyung Hwa Han Jin Young Kwak |
author_sort |
Soo-Yeon Kim |
title |
Ultrasound texture analysis: Association with lymph node metastasis of papillary thyroid microcarcinoma. |
title_short |
Ultrasound texture analysis: Association with lymph node metastasis of papillary thyroid microcarcinoma. |
title_full |
Ultrasound texture analysis: Association with lymph node metastasis of papillary thyroid microcarcinoma. |
title_fullStr |
Ultrasound texture analysis: Association with lymph node metastasis of papillary thyroid microcarcinoma. |
title_full_unstemmed |
Ultrasound texture analysis: Association with lymph node metastasis of papillary thyroid microcarcinoma. |
title_sort |
ultrasound texture analysis: association with lymph node metastasis of papillary thyroid microcarcinoma. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
This retrospective study aimed to evaluate whether ultrasound texture analysis is useful to predict lymph node metastasis in patients with papillary thyroid microcarcinoma (PTMC). This study was approved by the Institutional Review Board, and the need to obtain informed consent was waived. Between May and July 2013, 361 patients (mean age, 43.8 ± 11.3 years; range, 16-72 years) who underwent staging ultrasound (US) and subsequent thyroidectomy for conventional PTMC ≤ 10 mm between May and July 2013 were included. Each PTMC was manually segmented and its histogram parameters (Mean, Standard deviation, Skewness, Kurtosis, and Entropy) were extracted with Matlab software. The mean values of histogram parameters and clinical and US features were compared according to lymph node metastasis using the independent t-test and Chi-square test. Multivariate logistic regression analysis was performed to identify the independent factors associated with lymph node metastasis. Tumors with lymph node metastasis (n = 117) had significantly higher entropy compared to those without lymph node metastasis (n = 244) (mean±standard deviation, 6.268±0.407 vs. 6.171±.0.405; P = .035). No additional histogram parameters showed differences in mean values according to lymph node metastasis. Entropy was not independently associated with lymph node metastasis on multivariate logistic regression analysis (Odds ratio, 0.977 [95% confidence interval (CI), 0.482-1.980]; P = .949). Younger age (Odds ratio, 0.962 [95% CI, 0.940-0.984]; P = .001) and lymph node metastasis on US (Odds ratio, 7.325 [95% CI, 3.573-15.020]; P < .001) were independently associated with lymph node metastasis. Texture analysis was not useful in predicting lymph node metastasis in patients with PTMC. |
url |
http://europepmc.org/articles/PMC5395228?pdf=render |
work_keys_str_mv |
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