2-methoxyestradiol induces mitotic arrest, apoptosis, and synergistic cytotoxicity with arsenic trioxide in human urothelial carcinoma cells.

2-methoxyestradiol induces mitotic arrest, apoptosis, and synergistic cytotoxicity with arsenic trioxide in human urothelial carcinoma cells.

2-Methoxyestradiol (2-ME), an endogenous derivative of 17β-estradiol, has been reported to elicit antiproliferative responses in various tumors. In this study, we investigated the effects of 2-ME on cell viability, proliferation, cell cycle, and apoptosis in human urothelial carcinoma (UC) cell line...

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Main Authors: Kuan-Lin Kuo, Wei-Chou Lin, I-Lin Ho, Hong-Chiang Chang, Ping-Yi Lee, Yuan-Ting Chung, Ju-Ton Hsieh, Yeong-Shiau Pu, Chung-Sheng Shi, Kuo-How Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3742604?pdf=render

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http://europepmc.org/articles/PMC3742604?pdf=render

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