Role of Age-Related Mitochondrial Dysfunction in Sarcopenia
Skeletal muscle aging is associated with a significant loss of skeletal muscle strength and power (i.e., dynapenia), muscle mass and quality of life, a phenomenon known as sarcopenia. This condition affects nearly one-third of the older population and is one of the main factors leading to negative h...
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doaj-6feccdc245d84f509d049e6afd528b1c2020-11-25T03:39:20ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-01215236523610.3390/ijms21155236Role of Age-Related Mitochondrial Dysfunction in SarcopeniaEvelyn Ferri0Emanuele Marzetti1Riccardo Calvani2Anna Picca3Matteo Cesari4Beatrice Arosio5Geriatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyFondazione Policlinico Universitario “Agostino Gemelli” IRCCS, 00168 Rome, ItalyFondazione Policlinico Universitario “Agostino Gemelli” IRCCS, 00168 Rome, ItalyFondazione Policlinico Universitario “Agostino Gemelli” IRCCS, 00168 Rome, ItalyGeriatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyGeriatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalySkeletal muscle aging is associated with a significant loss of skeletal muscle strength and power (i.e., dynapenia), muscle mass and quality of life, a phenomenon known as sarcopenia. This condition affects nearly one-third of the older population and is one of the main factors leading to negative health outcomes in geriatric patients. Notwithstanding the exact mechanisms responsible for sarcopenia are not fully understood, mitochondria have emerged as one of the central regulators of sarcopenia. In fact, there is a wide consensus on the assumption that the loss of mitochondrial integrity in myocytes is the main factor leading to muscle degeneration. Mitochondria are also key players in senescence. It has been largely proven that the modulation of mitochondrial functions can induce the death of senescent cells and that removal of senescent cells improves musculoskeletal health, quality, and function. In this review, the crosstalk among mitochondria, cellular senescence, and sarcopenia will be discussed with the aim to elucidate the role that the musculoskeletal cellular senescence may play in the onset of sarcopenia through the mediation of mitochondria.https://www.mdpi.com/1422-0067/21/15/5236skeletal musclemuscle agingsarcopeniamitochondriamitochondrial dysfunction |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Evelyn Ferri Emanuele Marzetti Riccardo Calvani Anna Picca Matteo Cesari Beatrice Arosio |
spellingShingle |
Evelyn Ferri Emanuele Marzetti Riccardo Calvani Anna Picca Matteo Cesari Beatrice Arosio Role of Age-Related Mitochondrial Dysfunction in Sarcopenia International Journal of Molecular Sciences skeletal muscle muscle aging sarcopenia mitochondria mitochondrial dysfunction |
author_facet |
Evelyn Ferri Emanuele Marzetti Riccardo Calvani Anna Picca Matteo Cesari Beatrice Arosio |
author_sort |
Evelyn Ferri |
title |
Role of Age-Related Mitochondrial Dysfunction in Sarcopenia |
title_short |
Role of Age-Related Mitochondrial Dysfunction in Sarcopenia |
title_full |
Role of Age-Related Mitochondrial Dysfunction in Sarcopenia |
title_fullStr |
Role of Age-Related Mitochondrial Dysfunction in Sarcopenia |
title_full_unstemmed |
Role of Age-Related Mitochondrial Dysfunction in Sarcopenia |
title_sort |
role of age-related mitochondrial dysfunction in sarcopenia |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-07-01 |
description |
Skeletal muscle aging is associated with a significant loss of skeletal muscle strength and power (i.e., dynapenia), muscle mass and quality of life, a phenomenon known as sarcopenia. This condition affects nearly one-third of the older population and is one of the main factors leading to negative health outcomes in geriatric patients. Notwithstanding the exact mechanisms responsible for sarcopenia are not fully understood, mitochondria have emerged as one of the central regulators of sarcopenia. In fact, there is a wide consensus on the assumption that the loss of mitochondrial integrity in myocytes is the main factor leading to muscle degeneration. Mitochondria are also key players in senescence. It has been largely proven that the modulation of mitochondrial functions can induce the death of senescent cells and that removal of senescent cells improves musculoskeletal health, quality, and function. In this review, the crosstalk among mitochondria, cellular senescence, and sarcopenia will be discussed with the aim to elucidate the role that the musculoskeletal cellular senescence may play in the onset of sarcopenia through the mediation of mitochondria. |
topic |
skeletal muscle muscle aging sarcopenia mitochondria mitochondrial dysfunction |
url |
https://www.mdpi.com/1422-0067/21/15/5236 |
work_keys_str_mv |
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