Production of 68Ge, 64Cu, 86Y, 89Zr, 73Se, 77Br and 124I positron emitting radionuclides through future laser-accelerated proton beams at ELI-Beamlines for innovative PET diagnostics

• Main Authors: Antonio Italiano, Ernesto Amato, Fabio Minutoli, Daniele Margarone, Sergio Baldari
• Format: Article
• Language: English
• Published: Accademia Peloritana dei Pericolanti 2016-05-01
• Series: Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali
• Online Access: http://dx.doi.org/10.1478/AAPP.942A2

The development of innovative production pathways for high-Z positron emitters is of great interest to enlarge the applicability of PET diagnostics, especially in view of the continuous development of new radiopharmaceuticals. We evaluated the theoretical yields of 64Cu, 86Y, 89Zr, 73Se, 77Br and 124I PET isotopes, plus the 68Ge isotope, parent of the 68Ga positron emitter, in the hypothesis of production through laser-accelerated proton sources expected at the ELI-Beamlines facility. By means of the TALYS software we simulated the nuclear reactions leading to the above radionuclides, hypothesizing three possible scenarios of broad proton spectra, with maximum energies of about 9, 40 and 100 MeV. The production yields of the studied radionuclides, within the expected fluences, appear to be suitable for pre-clinical applications.