Digital Subtraction Phonocardiography (DSP) applied to the detection and characterization of heart murmurs

<p>Abstract</p> <p>Background</p> <p>During the cardiac cycle, the heart normally produces repeatable physiological sounds. However, under pathologic conditions, such as with heart valve stenosis or a ventricular septal defect, blood flow turbulence leads to the product...

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Main Authors: Ali Akbari Mohammad, Hassani Kamran, Doyle John D, Navidbakhsh Mahdi, Sangargir Maryam, Bajelani Kourosh, Ahmadi Zahra
Format: Article
Language:English
Published: BMC 2011-12-01
Series:BioMedical Engineering OnLine
Subjects:
Online Access:http://www.biomedical-engineering-online.com/content/10/1/109
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spelling doaj-6ff369e7deb2406e9fad054505fb7d672020-11-25T01:26:56ZengBMCBioMedical Engineering OnLine1475-925X2011-12-0110110910.1186/1475-925X-10-109Digital Subtraction Phonocardiography (DSP) applied to the detection and characterization of heart murmursAli Akbari MohammadHassani KamranDoyle John DNavidbakhsh MahdiSangargir MaryamBajelani KouroshAhmadi Zahra<p>Abstract</p> <p>Background</p> <p>During the cardiac cycle, the heart normally produces repeatable physiological sounds. However, under pathologic conditions, such as with heart valve stenosis or a ventricular septal defect, blood flow turbulence leads to the production of additional sounds, called murmurs. Murmurs are random in nature, while the underlying heart sounds are not (being deterministic).</p> <p>Innovation</p> <p>We show that a new analytical technique, which we call Digital Subtraction Phonocardiography (DSP), can be used to separate the random murmur component of the phonocardiogram from the underlying deterministic heart sounds.</p> <p>Methods</p> <p>We digitally recorded the phonocardiogram from the anterior chest wall in 60 infants and adults using a high-speed USB interface and the program Gold Wave <url>http://www.goldwave.com</url>. The recordings included individuals with cardiac structural disease as well as recordings from normal individuals and from individuals with innocent heart murmurs. Digital Subtraction Analysis of the signal was performed using a custom computer program called <b>Murmurgram</b>. In essence, this program subtracts the recorded sound from two adjacent cardiac cycles to produce a difference signal, herein called a "murmurgram". Other software used included Spectrogram (Version 16), GoldWave (Version 5.55) as well as custom MATLAB code.</p> <p>Results</p> <p>Our preliminary data is presented as a series of eight cases. These cases show how advanced signal processing techniques can be used to separate heart sounds from murmurs. Note that these results are preliminary in that normal ranges for obtained test results have not yet been established.</p> <p>Conclusions</p> <p>Cardiac murmurs can be separated from underlying deterministic heart sounds using DSP. DSP has the potential to become a reliable and economical new diagnostic approach to screening for structural heart disease. However, DSP must be further evaluated in a large series of patients with well-characterized pathology to determine its clinical potential.</p> http://www.biomedical-engineering-online.com/content/10/1/109Digital subtractionphonocardiographyMATLABMurmurgram
collection DOAJ
language English
format Article
sources DOAJ
author Ali Akbari Mohammad
Hassani Kamran
Doyle John D
Navidbakhsh Mahdi
Sangargir Maryam
Bajelani Kourosh
Ahmadi Zahra
spellingShingle Ali Akbari Mohammad
Hassani Kamran
Doyle John D
Navidbakhsh Mahdi
Sangargir Maryam
Bajelani Kourosh
Ahmadi Zahra
Digital Subtraction Phonocardiography (DSP) applied to the detection and characterization of heart murmurs
BioMedical Engineering OnLine
Digital subtraction
phonocardiography
MATLAB
Murmurgram
author_facet Ali Akbari Mohammad
Hassani Kamran
Doyle John D
Navidbakhsh Mahdi
Sangargir Maryam
Bajelani Kourosh
Ahmadi Zahra
author_sort Ali Akbari Mohammad
title Digital Subtraction Phonocardiography (DSP) applied to the detection and characterization of heart murmurs
title_short Digital Subtraction Phonocardiography (DSP) applied to the detection and characterization of heart murmurs
title_full Digital Subtraction Phonocardiography (DSP) applied to the detection and characterization of heart murmurs
title_fullStr Digital Subtraction Phonocardiography (DSP) applied to the detection and characterization of heart murmurs
title_full_unstemmed Digital Subtraction Phonocardiography (DSP) applied to the detection and characterization of heart murmurs
title_sort digital subtraction phonocardiography (dsp) applied to the detection and characterization of heart murmurs
publisher BMC
series BioMedical Engineering OnLine
issn 1475-925X
publishDate 2011-12-01
description <p>Abstract</p> <p>Background</p> <p>During the cardiac cycle, the heart normally produces repeatable physiological sounds. However, under pathologic conditions, such as with heart valve stenosis or a ventricular septal defect, blood flow turbulence leads to the production of additional sounds, called murmurs. Murmurs are random in nature, while the underlying heart sounds are not (being deterministic).</p> <p>Innovation</p> <p>We show that a new analytical technique, which we call Digital Subtraction Phonocardiography (DSP), can be used to separate the random murmur component of the phonocardiogram from the underlying deterministic heart sounds.</p> <p>Methods</p> <p>We digitally recorded the phonocardiogram from the anterior chest wall in 60 infants and adults using a high-speed USB interface and the program Gold Wave <url>http://www.goldwave.com</url>. The recordings included individuals with cardiac structural disease as well as recordings from normal individuals and from individuals with innocent heart murmurs. Digital Subtraction Analysis of the signal was performed using a custom computer program called <b>Murmurgram</b>. In essence, this program subtracts the recorded sound from two adjacent cardiac cycles to produce a difference signal, herein called a "murmurgram". Other software used included Spectrogram (Version 16), GoldWave (Version 5.55) as well as custom MATLAB code.</p> <p>Results</p> <p>Our preliminary data is presented as a series of eight cases. These cases show how advanced signal processing techniques can be used to separate heart sounds from murmurs. Note that these results are preliminary in that normal ranges for obtained test results have not yet been established.</p> <p>Conclusions</p> <p>Cardiac murmurs can be separated from underlying deterministic heart sounds using DSP. DSP has the potential to become a reliable and economical new diagnostic approach to screening for structural heart disease. However, DSP must be further evaluated in a large series of patients with well-characterized pathology to determine its clinical potential.</p>
topic Digital subtraction
phonocardiography
MATLAB
Murmurgram
url http://www.biomedical-engineering-online.com/content/10/1/109
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