Phagosomal TLR signaling upon Borrelia burgdorferi infection
Internalization of live Borrelia burgdorferi followed by their degradation within phagosomal compartments, allows for the release not only of lipoproteins but of other microbial products, such as nucleic acids, needed to elicit a full and broad inflammatory response in monocytes/macrophages. Toll-l...
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doaj-6ff841a6862d4dfba2ce1202f842782f2020-11-24T22:29:04ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882014-05-01410.3389/fcimb.2014.0005589771Phagosomal TLR signaling upon Borrelia burgdorferi infectionJorge Luis Cervantes0Kelly Lynn Hawley1Kelly Lynn Hawley2Sarah Jane Benjamin3Bennett eWeinerman4Stephanie eLuu5Juan Carlos Salazar6Juan Carlos Salazar7University of Connecticut Health CenterUniversity of Connecticut Health CenterConnecticut Children’s Medical CenterUniversity of Connecticut Health CenterUniversity of Connecticut Health CenterUniversity of Connecticut Health CenterUniversity of Connecticut Health CenterConnecticut Children’s Medical CenterInternalization of live Borrelia burgdorferi followed by their degradation within phagosomal compartments, allows for the release not only of lipoproteins but of other microbial products, such as nucleic acids, needed to elicit a full and broad inflammatory response in monocytes/macrophages. Toll-like receptors (TLRs) are key players in the recognition of ligands from whole viable organisms (i.e. vita-PAMPs). Although the immune system has evolved mechanisms to prevent stimulation by self-nucleic acids, nucleic acid-sensing TLRs can trigger innate immune activation resulting in induction of autoimmunity. Endosomal TLR variations could not only lead to an increased susceptibility to Lyme disease, but also determine the severity of its clinical symptoms. With a deeper understanding of the TLR pathways, we will be able to create better treatments and more thoroughly understand the mechanism of disease in patients.http://journal.frontiersin.org/Journal/10.3389/fcimb.2014.00055/fullBorrelia burgdorferiLyme DiseaseToll-Like Receptorsinnate immunityphagosomal signaling |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jorge Luis Cervantes Kelly Lynn Hawley Kelly Lynn Hawley Sarah Jane Benjamin Bennett eWeinerman Stephanie eLuu Juan Carlos Salazar Juan Carlos Salazar |
spellingShingle |
Jorge Luis Cervantes Kelly Lynn Hawley Kelly Lynn Hawley Sarah Jane Benjamin Bennett eWeinerman Stephanie eLuu Juan Carlos Salazar Juan Carlos Salazar Phagosomal TLR signaling upon Borrelia burgdorferi infection Frontiers in Cellular and Infection Microbiology Borrelia burgdorferi Lyme Disease Toll-Like Receptors innate immunity phagosomal signaling |
author_facet |
Jorge Luis Cervantes Kelly Lynn Hawley Kelly Lynn Hawley Sarah Jane Benjamin Bennett eWeinerman Stephanie eLuu Juan Carlos Salazar Juan Carlos Salazar |
author_sort |
Jorge Luis Cervantes |
title |
Phagosomal TLR signaling upon Borrelia burgdorferi infection |
title_short |
Phagosomal TLR signaling upon Borrelia burgdorferi infection |
title_full |
Phagosomal TLR signaling upon Borrelia burgdorferi infection |
title_fullStr |
Phagosomal TLR signaling upon Borrelia burgdorferi infection |
title_full_unstemmed |
Phagosomal TLR signaling upon Borrelia burgdorferi infection |
title_sort |
phagosomal tlr signaling upon borrelia burgdorferi infection |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2014-05-01 |
description |
Internalization of live Borrelia burgdorferi followed by their degradation within phagosomal compartments, allows for the release not only of lipoproteins but of other microbial products, such as nucleic acids, needed to elicit a full and broad inflammatory response in monocytes/macrophages. Toll-like receptors (TLRs) are key players in the recognition of ligands from whole viable organisms (i.e. vita-PAMPs). Although the immune system has evolved mechanisms to prevent stimulation by self-nucleic acids, nucleic acid-sensing TLRs can trigger innate immune activation resulting in induction of autoimmunity. Endosomal TLR variations could not only lead to an increased susceptibility to Lyme disease, but also determine the severity of its clinical symptoms. With a deeper understanding of the TLR pathways, we will be able to create better treatments and more thoroughly understand the mechanism of disease in patients. |
topic |
Borrelia burgdorferi Lyme Disease Toll-Like Receptors innate immunity phagosomal signaling |
url |
http://journal.frontiersin.org/Journal/10.3389/fcimb.2014.00055/full |
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